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Showing 1 to 20 of 159 for “"T helper"”.
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Transcription factor regulation of T helper subset function
… The development of specialized subsets of T helper cells is governed by transcription factors. Previous work demonstrated a requirement for the transcription factor PU.1 in the development of IL-9-secreting Th9 cells. Work in this dissertation demonstrates that the Th9 subset is not stable in …
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… specificity strongly support the role of CD4 T helper cells in the pathogenesis of AAV. Recently a new subset of T cells called peripheral T helper (PTH) cells, characterised by the PD1+CXCR5- phenotype, was described in the context of auto-immune diseases, driving organ inflammation. These …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to pathogenicity in EAE/MS. We examined the use of T-bet specific AS …
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Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
Despite considerable progress in conventional cancer therapies, major challenges persist in the treatment of patients with advanced stage malignancies. Cancer immunotherapy (harnessing the immune system against tumors) has demonstrated limited success to date, partially due to the immunosuppressive …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… the differentiation of activated naïve T helper (Th) cells into Th1, Th2, Th17 or T regulatory (Treg) cells. We show that bone marrow-derived DC (BMDC) differentiated from old male mice stimulated with Toll-like receptor (TLR) agonists, alone or in combination, secrete increased IL-23, a …
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Stochastic gene expression during lineage specification of single T helper lymphocytes
… during the lineage specification of single T helper cells, by quantitatively measuring mRNA and protein levels. I have discovered a paradigm of cell lineage specification governed by the signaling interplay between extracellular cues and intracellular transcriptional factors, where the …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… subsets based on their effector functions. T helper 9 (Th9) cells, derived by the IL-4/STAT6 and TGF-β signaling pathways, produce IL-9 as a hallmark cytokine, as well as IL-10. Through IL-9 production, Th9 cells protect against parasite infection but are also involved in allergic inflammation …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… been shown to directly promote inflammatory T helper 1 (Th1) and T helper 17 (Th17) cell differentiation and function. Since T cells have a critical role in driving inflammation and systemic glucose intolerance in obesity, we sought to determine the role of leptin signaling in this context. …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
Activation of pattern recognition receptors on dendritic cells (DCs) and macrophages leads to secretion of cytokines that control activation and differentiation of CD4+ T cells. While IL-12 is critical for Th1 lineage development, IL-6 and TGF-b play an important role in differentiation of Th17 …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
<p>CD4<sup>+</sup> T helper (Th) lymphocytes are vital for integrating immune responses by orchestrating the function of other immune cell types. Naïve Th cells can differentiate into different effector subsets that are characterized by their cytokine profile and immune regulatory functions. These …
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The generation and maintenance of T Helper 17 cells in response to bacterial infection
… (TGF-β1) as sufficient to induce T helper type-17 (TH17) differentiation in vitro, but it is unclear whether these factors are necessary, and if so, what the cellular source of these factors is in the context of a TH17 inducing infection in vivo. Moreover, studies of the TH17 …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We wished to study the regulation of this process by transcription factors STAT3 and Bcl6. STAT3 is important for …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu by activating Signal Transducer and …
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
<p>Hypersensitivity Pneumonitis (HP) is an interstitial lung disease caused by repeated inhalation of a wide range of environmental antigens. It is characterized by alveolitis, granuloma formation, and fibrosis. Since HP is a T cell-mediated disease, it is important to determine the type of T cell …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
… ER stress response acts as a potent driver of T helper 17 (Th17) cell differentiation resulting in Th17 cells with a pathogenic gene expression signature. This suggests a link between ER stress-inducing conditions such as low nutrient availability, and the pathology of Th17 cell-mediated …
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Protein Kinase A regulates GATA-3 dependent Activation of IL-5 Gene Expression in T Helper Lymphocytes
Die durch Agentien wie IL-1α, Prostaglandine oder Forskolin induzierte Erhöhung von intrazellulärem zyklischem Adenosin-Monophosphat (cAMP) in T-Lymphozyten inhibiert die Synthese Th1-typischer Zytokine und stimuliert die Synthese Th2-typischer Zytokine. Die für die cAMP-vermittelte Induktion von …
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Engineering T Cell Receptors to Examine the Role of Affinity and *Kinetics in T Helper Cell Function
Chapter five details the engineering of a class II restricted human TCR isolated from a patient with multiple sclerosis called 3A6. Yeast display of TCRs has previously relied on the use of an antibody specific for a properly folded TCR, here various strategies were used to generate stabilized 3A6 …
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Suppression of T-Helper Cell Function by a Soluble Immunosuppressive Factor From Plasmodium Berghei Infected Rat Erythrocytes
… when supplemented with the appropriate T-helper cells. T-helper cells from ISF treated mice failed to supplement naive B cells in a primary in vitro anti-SRBC response as successfully as cells from untreated mice. Interleukin 2 production was not affected by the ISF. Treatment of infected …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… of immune responses is coordinated by CD4+ T-helper (Th) cells. Depending on the cytokine environment, Th progenitor (Thp) cells differentiate into three functionally different effector subsets. T-helper-1 (Th1) cells which mediate cell-mediated immunity, T-helper-2 (Th2) which orchestrates …
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