Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"T follicular helper cells"”.
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Mathematical Models of Immune Responses to Infectious Diseases
… potent long-lived plasma. We predict that the T follicular helper cells are a limiting resource and present possible mechanisms that can revert this limitation in the presence of non-mutating and mutating antigen. Finally, we develop a pharmacokinetic model of 3BNC117 antibody dynamics and HIV …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
Regulatory T (Treg) cells suppress CD4+ T cell responses during homeostasis and inflammation to prevent autoimmunity and other immune disorders. Although the transcriptional and epigenetic programs impacting Treg cell function have been extensively studied, the signaling and metabolic pathways …
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Characterization of Allergen-Specific Immunoglubulin E Development in a Food Allergy Model and Its Regulation by T Follicular Helper and T Follicular Regulatory Cells
… development of IgE is regulated by T follicular helper cells (TFH) and T follicular regulatorycells (TFR) in the germinal center (GC). We aimed to understandthe regulation of IgEin the GC by TFH and TFR cellsusinga mouse food allergy model. We found that the dosage and timingof …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… for testing of novel therapeutic agents. Donor T-cells, responsible for the initiation disease, require specific signaling pathways and changes in their metabolic profile to sustain their survival, proliferation and differentiation. In cGVHD, activated donor CD4+ T-cells differentiate into …
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… against autoimmunity and infectious disease. B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way their B cell receptors bind antigen and generate antibodies that provide protection against infections. Due to their de novo formation and less stringent …
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B Cell Receptor Signalng in Germinal Centers
… This process is limited and directed by T follicular helper cells that provide helper signals to B cells that endocytose, process, and present cognate antigens in proportion to receptor affinity. GCs play a crucial role in immunity by generating an evolving B cell pool that serves as the …
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T cell phenotyping of a mouse model of Activated PI3Kdelta syndrome
… Following T cell receptor (TCR) stimulation, T cells from these patients undergo increased activation induced cell death, which can be reversed by selective PI3Kdelta inhibitors. I used a new conditional knock-in mouse (T-p110delta E1020K) in order to investigate the effect of hyperactive …
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
… vaccination through the production of memory B cells and long-lived antibody-secreting plasma cells. However, the GC response deteriorates with age contributing to poor humoral immunity after vaccination and therefore to increased susceptibility to infections in older individuals. I aimed to …
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Antibody-Mediated Modulation of Polyclonal Immune Responses
… line of defense, and consists mainly of myeloid cells that are quickly activated within hours to days to engage in a non-specific manner. This broad response is followed by the adaptive immune response, which progresses more slowly but is capable of generating pathogen-specific immunity. …
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Influence of helminth infection on vaginal immunity
… of wild type BALB/c mice resulted in increased B cells, IgG1+ B cells and IgG1+ follicular B cells as well as increased effector memory T cells and T follicular helper cells in iliac lymph nodes, which drain the female reproductive tract. We then infected wild type BALB/c mice with Nippostrongylus …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
T follicular helper (Tfh) cells represent a CD4+ T cell subset specialized for B-cell help. While our knowledge on the biology of Tfh cells has dramatically increased during the past decade, a vast majority of observations were made in mouse models. Our knowledge on the biology of human Tfh cells …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… important molecular pathways in diverse immune cells. Both innate and adaptive immune cells contribute to pathogenesis of lupus. Among those cells, B cells play a central role in pathogenesis of lupus nephritis in an anti-body dependent manner through differentiation into plasma cells (PCs). As …