Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"T cell trafficking"”.
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… LFA-1 inhibitor compounds, which inhibit early T-cell trafficking of the adaptive immune system, and the development and evaluation of release kinetics of novel prodrugs of one of these novel LFA-1 inhibitors with poor leaving group ability under physiological conditions. Evaluation of the …
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A three-dimensional agent-based model of glioblastoma with applications towards in vitro and in vivo therapy simulation
… these subtypes lead to downstream differences in cell migration speed and immune system activation status. Despite these behavioral differences, glioblastomas are treated using a uniform standard of care regardless of tumor subtype. To identify subtype-dependent features influencing tumor …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
The CD8+ T cell responses play a pivotal role in controlling viral replication during HCV infection. HCV evades the immune system by rapid viral evolution affording escape from immune selection pressure including at MHC-I restricted epitopes. However, some CTL epitopes remain conserved well past …
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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis
… a chronic pulmonary disease caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb). Even though CD4 T cells are critical for containing Mtb, the immune system rarely eradicates the bacteria, necessitating the maintaining of an antigen-specific CD4 T cell response throughout the …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
… and peripheral organs. Thus, the inhibition of T cells trafficking through S1P1 receptor modulation is a potential translational approach to protect the heart in diabetes. We hypothesized that inhibition of T lymphocyte trafficking by modulating S1P1 receptor protects diabetic heart and …
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Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis
Toxoplasma gondii, an obligate intracellular protozoan parasite, establishes a latent, chronic infection by forming cysts preferentially in the brain after replication of tachyzoites in various organs during the acute stage of infection. Chronic infection with T. gondii is one of the most common …