Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"T cell tolerance"”.
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The Role of NDFIP1 in T Cell Tolerance
… mechanisms to contain the activity of immune cells are necessary to prevent immune responses against non-pathogenic antigens and the severe immunopathology that would otherwise result. In T cells, these mechanisms are termed T cell tolerance. T cell tolerance is defined as the collection of T …
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Overcoming T Cell Tolerance Against Endogenous Choroid Plexus Tumors Using a Combination Immunotherapy
We target T cells escaping clonal deletion to study effects of a combination of immunotherapies against endogenously arising choroid plexus tumors. The model we use is the SV11 mouse transgenic for large T antigen of simian virus 40. Mice are immunologically tolerant to the choroid plexus tumor. We …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
<p>Dendritic cells (DCs) play a pivotal role in determining whether the outcome of the immune system's encounter with antigen will be immunity or tolerance. Using an antibody against the DEC-205 receptor, antigens have been delivered specifically to DCs in vivo. Under steady state conditions, such …
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Investigating immune surveillance, tolerance, and therapy in cancer
… closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems largely relied on chemically-induced and spontaneous tumors in immunodeficient mice or on transplanted tumors. Such systems are limited because they …
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Staphylococcal Enterotoxin B Induced Clonal Anergy in αβ T Cell Receptor Transgenic Mice
… B (SEB) have been widely used to study T cell tolerance. While both clonal deletion and apparent anergy have been described in response to superantigens, it has not been clear whether true anergy occurs, or whether the most reactive T cells are selectively deleted, leaving less reactive …
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Selection Methods For Genetically-Modified T Cells: In Support of Translational Therapy
<p>T cells are blood cells which organize the immune system of the host. These cells are necessary for the host to respond appropriately to threats from foreign organisms and cancerous growth. However, in the case of certain infections and cancer, T cells are unable to respond appropriately to a …
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Delineating the Role of CD244 in NK Cell Cytotoxicity and the Contribution of Ly108 to Thymocyte Development
… and Ly108 (NTB-A)) as causative for a breach in tolerance of both T and B cells leading to the production of self reactive antibodies. Analysis of common strains of laboratory mice revealed the existence of two stable haplotypes (b and z) of the SLAM family gene cluster. Given recent studies …
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Pathogenic Mechanisms Underlying Immune Dysregulation Associated To Hypomorphic RAG2 Mutation: Role Of Microbiota At Mucosal Interfaces
… mediated by oligoclonal self-reactive T and B cells, named Omenn Syndrome (OS). The clinical and immunological spectrum of OS presentation is extremely broad. Commonly, patients present symptoms very similar to graft-versus-host disease (GVHD) as inflammatory reactions particularly involve the …
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Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function
… receptor, FcRn, is expressed in many different cell types and serves several functions, some of which are cell type-specific. A function common to most cell types that express this receptor is salvage of IgG from cellular degradation which is responsible for the long in vivo half-life of IgG. …
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Immunological mechanisms controlling chronic inflammatory diseases
… diseases (CID) mediated by self-reactive T and B cells and are generally the results of the breakdown of T cell tolerance to self-antigen and failure of peripheral regulatory mechanisms. In this thesis I studied different mechanisms controlling the development of CIDs. I investigated the initial …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
IL-10-treated tolerogenic dendritic cells (DC10) have been used as a powerful tool for the treatment of experimental asthmatic responses. We explored the important role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA …
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Altered Expression of Costimulatory Molecules in Behcet's Disease According to Clinical Activity
… failure to control autoreactive immune cells in the periphery may play a crucial role in BD. To produce a balanced immune response, key inhibitory costimulartory molecules that critically affect peripheral T cell tolerance and T cell function includes the cytotoxic T-lymphocyte antigen-4 …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… but also for a state of antigen-specific tolerance to be elicited against harmless antigens. A breakdown in such tolerance can result in the development of a variety of autoimmune diseases including rheumatoid arthritis, Type 1 diabetes, inflammatory bowel disease and coeliac disease. …