Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"T cell signalling"”.
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… to self antigens is to prevent self-reactive T cells from exiting the thymus following their development therein (central tolerance). However, some self-reactive T cells escape thymic deletion and as such, central tolerance is incomplete. Indeed, peripheral tolerance is required for an …
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Development of an Optogenetic Toolkit for the Interrogation of T cell Signalling Dynamics
T cells are a cornerstone of the mammalian adaptive immune system. A range of T-cell subsets exist that can orchestrate the overall immune response to pathogens or cancers, either by directly killing infected cells or licensing other cells to do so. Dysregulation of this important process can …
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From Biology to Algorithms
… the thesis investigates a detailed model of T cell signalling process. The model is subjected to stochastic analysis which results in a hypothesis for T cell activation. This hypothesis is abstracted to form a simplified model which retains key mechanisms. The abstracted model is shown to have …
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A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO
… measurement of kinetic ligand responses across cell signalling networks at the single-cell level in distinct PBMC subtypes ex vivo. Using automated sample preparation, fluorescent cellular barcoding and flow cytometry the platform is capable of detecting 21, 840 parallel cell signalling …
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Differential regulation and functions of the ZFP36-family RNA binding proteins in CD8⁺ memory T cells
CD8⁺ T cells target infected or malignant cells via cytotoxicity and the production of pro inflammatory cytokines and chemokines. In addition to antigen-specific responses mediated by the TCR, pro-inflammatory cytokines such as IL-12 and IL-18 can induce antigen-independent bystander activation of …