Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"T cell signaling"”.
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Regulation of T-cell signaling networks
… of how biology carries information within cells, it is not sufficient to look at individual protein or gene interactions, but to understand these networks of interactions as a whole. The goal of this thesis is to understand various aspects of how cells in general and T-cells in particular …
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Stochastic processes in T-cell signaling
T cells are orchestrators for adaptive immunity. Antigen recognition by T cells is mediated by the interactions between T-cell receptors (TCRs) and peptide-MHC (pMHC) molecules. How T cells can translate stimulatory external cues (e.g., TCRpMHC interactions where the peptides are derived from …
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Stochastic and spatiotemporal effects in T-cell signaling
… and the physical sciences to understand how T cells balance the risks of autoimmunity and infection. (1) What features of proteins do T cells search for that correlate with pathogenicity, distinguishing self from foreign? Two contrasting theories have emerged that attempt to describe T cell …
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The roles of clustered membrane proteins in T-cell signaling
… that can respond to diverse pathogens. Mature T cells, one of the most important immune cells generated from the thymus through a rigorous selection processes, are key orchestrators of the immune responses. Although many of the key signaling molecules in T cells have been discovered, the …
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Defining the Role of CD3 Zeta ITAMs in T Cell Signaling and Development
Alpha beta T cells express a T cell receptor (TCR) composed of an alpha beta heterodimer that is responsible for ligand recognition, which is associated with six invariant signaling chains, termed the CD3 subunits. These are organized into two independent signaling modules, the CD3 gamma epsilon / …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
T cell development is regulated by signals generated in the interactions between developing thymocytes and the thymic stroma. Using fetal thymus organ culture (FTOC) as a model of T cell development, we investigated the ability of two potent signal modulators to influence this process. These …
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ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
Immune stimulation fuels cell signaling-transcriptional programs that induce biological responses to eliminate virus-infected cells. Yet, retroviruses that integrate into host cell chromatin, such as HIV-1, co-opt these programs to switch between latent and reactivated states. However, many …
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Actin Regulatory Dynamics Required for T Cell Activation: A Quantitative and Systems-Level Perspective
T cell activation occurs through interaction with an antigen-presenting cell (APC). Upon activation, signaling ensues with the coordination of dozens of diverse signaling molecules in space and time, a feature of cell signaling we call ‘spatiotemporal patterning’. We performed a systems-scale …
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Characterization of Antigen Recognition by a T Lymphocyte Clone
Chapter Four addresses the physiological T cell responses that can be elicited by peptide/MHC recognition. We demonstrated that the endogenously derived peptide, dEV8, functioned as both an agonist and an antagonist of T cells derived from 2C TCR transgenic mice. Although the exact mechanism …
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Bayesian network models of biological signaling pathways
Cells communicate with other cells, and process cues from their environment, via signaling pathways, in which extracellular cues trigger a cascade of information flow, causing signaling molecules to become chemically, physically or locationally modified, gain new functional capabilities, and affect …
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PHF6 modulates the chromatin landscape in B-cell leukemia
… factors. We show that loss of Phf6 in B-cell leukemia results in systematic changes in gene expression via alteration of the chromatin landscape at the transcriptional start sites of B- and T-cell specific factors. Additionally, Phf6KO cells show significant down-regulation of genes …
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Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following Discontinuation of ART
… early upregulation of pathways related to T cell signaling, cytokine responses, and metabolism prior to detectable plasma viremia, presumably reflecting initial viral replication in tissues. Taken together, these data provide a detailed anatomic, virologic, and immunologic characterization of …
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T-cell Dysfunction by HCV Core Protein Involves PD-1/PD-L1 Signaling.
… study we report that PD-1 is upregulated in T-cells from persons with chronic HCV infection when compared to healthy donors. In addition, PD-1 and PDL-1 are upregulated on T-cells from healthy donors when exposed to extracellular HCV core protein (a nucleocapsid protein that is …
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Mitigating and exploiting stochasticity in the immune system
… adaptive immune system of higher organisms, T cells are responsible for detecting infections and mounting a response. It is of great importance that T cells respond accurately to very small traces of pathogenic signal in a background sea of healthy cells, to which mounting an immune response in …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
Regulatory T cells are one of the integral components of the adaptive immune system that contribute to the regulation of anti-tumor T cell responses. However, studies have suggested that alterations in T cell signaling networks can result in T cells that are resistant to the suppressive effects of …
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Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands
… III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated yet powerful tool. …
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Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells
Autologous activated T cells (ATC) are being utilized in clinical trials as potential mediators of anti-tumor cytotoxicity in refractory cancer patients who suffer from hematologic malignancies or solid tumors. ATC are readily generated from peripheral blood and possess non-major histocompatibility …
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Develoment and Application of Chemical Strategies to Study Protein Fatty-Acylation in Eukaryotes
… is regulated in vivo, mechanisms that mediate cellular stimuli-driven changes of the lipid modification are not understood. Furthermore, the requirement for substrate specificity among the highly redundant palmitoyl acyltransferases (PATs) remains unresolved. To study the regulation of PATs and …
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Investigating The Distinct Role of Pd-L2 In Modulating Human T Cells Responses
… THE DISTINCT ROLE OF PD-L2 IN MODULATING HUMAN T CELL RESPONSES</strong></p> <p>Anupallavi Srinivasamani, M.S.</p> <p>Advisory Professor: Michael A. Curran, Ph.D.</p> <p>Therapeutic blockade of the Programmed cell death-1 (PD-1) receptor and its ligand Programmed death ligand-1 (PD-L1) has …
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Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL): Surplus to requirements or a protagonist in lymphomagenesis?
Anaplastic Large Cell Lymphoma (ALCL) is a peripheral T cell lymphoma divided into three distinct entities: ALCL, Anaplastic Lymphoma Kinase (ALK)+, ALCL ALK- and cutaneous ALCL. In the majority of ALCL, ALK+, ALK is expressed as the result of a chromosomal translocation generating Nucleophosmin …
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