Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 248 for “"T cell responses"”.
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Intestinal CD4+T Cell Responses to Food
… Oral tolerance requires CD4<sup>+</sup> T cells including specifically regulatory T cells (Tregs), however the role of intestinal CD4<sup>+</sup> T cells and the T cell repertoire in a physiological response to food protein remains largely unexplored. To characterize intestinal T cell …
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Long-Term T Cell Responses in the Ischemic Brain
… immune system. These early inflammatory responses result in the recruitment of systemic immune cells into the brain parenchyma. T lymphocytes, part of the adaptive arm of the immune response, are present bordering the infarct region within days after stroke. Accumulation of these cells in …
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Long-Term T Cell Responses in the Ischemic Brain
… immune system. These early inflammatory responses result in the recruitment of systemic immune cells into the brain parenchyma. T lymphocytes, part of the adaptive arm of the immune response, are present bordering the infarct region within days after stroke. Accumulation of these cells in …
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Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
CD8+ T cells play a central role in immunity against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit vaccines using whole protein or peptide epitopes are becoming increasingly …
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Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
… and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T cell phenotypes associated with latent infection and active disease. Ex vivo IFN? Elispots and …
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Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… by reinvigorating pre-existing anti-tumor immune responses, and responders are often characterized by the presence of a T cell infiltrate in tumors. However, T cell infiltration does not always correspond to ICB efficacy. Tumor-reactive T cells can acquire persistent dysfunctional states, which …
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Helicobacter pylori Type 4 Secretion System Modulates Host T Cell Responses
… cancer. During H. pylori infection CD4+ T cells in the gastric lamina propria are hyporesponsive and polarized to Th1/Th17 cell responses controlled by Treg cells. Gastric epithelial cells (GECs) are the primary target for H. pylori infection and may act as antigen-presenting cells (APCs) …
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Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses
… has been placed on stimulating mucosal immune responses with vaccines as mucosal surfaces function as a first line of defense against infections. Progress made in nanoparticle research, in particular the successful use of liposomes for drug delivery, has made liposomes an attractive candidate …
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T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection
The human pathogen Trypanosoma cruzi is an intracellular parasite and the etiological agent of Chagas disease. Protective immune responses to T. cruzi are highly dependent on T helper 1 and CD8+ T cells which produce interferon-gamma. A deficiency in these responses has severe consequences on the …
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Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
… Therefore, an important question arises: are T cells specific to these proteins generated, and, if so, why are HCMV latently infected cells maintained in the face of these potential T cell responses? Previous work has shown that two such viral gene products, UL138 and LUNA, are recognised by …
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Novel strategies for characterizing T Cell responses in SIV-infected rhesus monkeys
… growing. HIV infects and depletes CD4+ helper T cells, affecting the ability of the immune system to defend the host against common infections. While anti-retroviral therapy has decreased morbidity and mortality, these drugs are not curative. In addition, they are beyond the financial reach of …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… immunoregulatory pathway for modulating CD8+ T cell responses. This pathway has become an important therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves outcomes. However, it remains unclear how PD-1 pathway signals …
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Enhancing T-Cell Responses to Vaccination of HIV-1 infected Subjects on Antiretroviral Therapy
… with HIV-1. Even with the benefits to CD4+ cell counts, decrease in viremia and inflammatory biomarkers, HIV-1 infected individuals continue to exhibit functional issues in their T-cell immune responses to recall antigens and vaccines. Additionally, researchers believe that T-cell mediated …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the …
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Characterising the magnitude and breadth of T cell responses to SARS-CoV-2 vaccination
… 2 (SARS-CoV-2) is targeted by the CD4 and CD8 T cells. While most studies frequently measure the magnitude of spike-specific CD4 and CD8 responses, only a few studies have characterised their breadth of targeting across the spike. This characterization is crucial for predicting cross-reactivity …
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Phenotypic and functional characterisation of cervical and peripheral HIV-1 specific T cell responses
… may similarly result in differences in HIV T cell responses. There have been no studies of the maturational status of HIV-specific T cells present at the female genital mucosa. This study aimed to characterise HIV-specific cervical immune responses and to determine if compartmentalized immune …
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment
… therapy is limited by the tolerization of CD8⁺ T cells in tumors, rapidly abrogating anti-tumor responses. In order to better understand the factors necessary to induce, maintain and promote productive T cell responses against cancer, this research has focused on understanding and interrupting …
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T-cell responses to human papillomavirus in men with anal high-grade squamous intraepithelial lesions
… per year. To further understand the role of the cellular immune response in anal HSIL spontaneous regression, two assays were developed to measure systemic HPV16-specific T-cell responses and applied to a cross-sectional substudy of the Study of the Prevention of ANal Cancer (SPANC), a …
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Induction of myosin cross-reactive antibody and cytolytic T cell responses in mice with Streptococcus pyogenes
… mice to mount a myosin-reactive CD8+ cytotoxic T cell response following immunization with S. pyogenes. Our observations indicate that the response is additionally dependent on the genetic background of mice, the route of immunization, and requires M protein.;In summation, our results suggest that …
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