Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"T cell response"”.
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CD8⁺ T Cell Response to Influenza Virus
… effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to …
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The CD4⁺ T Cell Response to Human Cytomegalovirus
… In the healthy host, it elicits a broad immune response involving both the innate and adaptive arms of immunity, which is able to limit viral replication and prevent end-organ disease. However, like all herpesviruses, the virus then establishes a lifelong latent infection such that the host is …
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CD4+ T cell response against food antigens in intestinal disease
… system, in particular antigen-specific CD4+ T cells, are thought to play a key role in this process, but the exact mechanisms leading to the development and maintenance, as well as the failure, of oral tolerance are still not fully understood. T cells that recognize one particular antigen are …
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Constraints on the CD8 T cell response in chronic HBV infection
… by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total circulating and intrahepatic CD8 T cells in CHB patients and healthy donors. …
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Mechanistic insights into how collective effects mediate the T cell response
T cells play an important role in the adaptive immune system by providing robust responses to foreign pathogens while avoiding widespread autoimmunity. Although many specific microscopic factors are thought to contribute to this self/non-self discrimination, based on a theoretical paper and …
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Modulation of the T cell response with MHC class I peptides and their analogues
… to the activation of the recipient’s alloimmune response as a major determinant of transplant outcome. T cell recognition of foreign MHC molecules plays a key role in initiating and sustaining allograft rejection. To prevent the risk of rejection, patients are given immunosuppressive drugs, which …
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Changes in the BCG-Induced T cell response over the first year of life
… many gaps in our knowledge of BCG-induced T cell responses exist. The primary objective of this study was to comprehensively delineate T cell immunity induced by BCG vaccination of newborns and to longitudinally assess BCG-specific T cell responses over the first year of life.
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
… or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic and latent gammaherpesvirus infection, as demonstrated in the well-established murine model of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 …
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The Role of CD4+ T cells in the CD8+ T cell Response to Vaccinia Viral Infection
<p>The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens remains incompletely defined. The primary CD8 T response to infections was initially thought to be largely independent of CD4 T cells, but it is not clear why some primary, pathogen-specific CD8 T …
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Systems analysis of the CD4 T cell response induced by the novel subunit tuberculosis vaccine, H1:IC31
… comprehensively analyse antigen-specific CD4 T cell responses induced by vaccination and to examine the effects of latent M. tb infection on these responses. We had two broad objectives: Firstly, to determine the effects of latent M. tb infection on epitope recognition by mycobacteria-specific …
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Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
… affected the quantity and quality of T cell response and subsequent anti‐tumor efficacy. Here we describe L‐tyrosine amino acid‐based microparticles as a novel peptide vaccine adjuvant for the induction of tumor‐specific T cells. L‐tyrosine microparticles did not induce inflammasome …
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Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection
… order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must be alerted to the presence of infection in the periphery. This occurs as a result of presentation of pathogen derived epitopes on professional antigen presenting cells (APC), …
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The Efficacy of DNA Vaccine Using a Sindbis Virus-based Vector Against Nucleocapsid Protein of Hantaan Virus
… to be critical against viral infections, the cellular immune responses to HTNV are also assumed to be important for viral clearance. This study has examined the cellular and humoral immune responses against the HTNV nucleocapsid protein (NP) elicited by virus infection or DNA vaccination to …
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Development and characterization of immunogenic genetically engineered mouse models of pancreatic cancer
… to dissect the endogenous antigen-specific T cell response in PDAC, lentivirus encoding the Cre recombinase and a tumor specific antigen (SIINFEKL, OVA[subscript 257-264]) was delivered to Kras[superscript LSL-G12D/+]; Trp[superscript 53flox/flox] (KP) mice. We demonstrate that KP tumors show …
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The Role of Gammadelta T Cells and CD8+ Memory T Cells in Vaccinia Viral Infection
<p>Immune responses against viral infections are mediated through a complex process by diverse populations of cells, that can be harnessed for tumor immunotherapies and vaccinations. Vaccinia virus (VV) is the most studied member of the poxvirus family and is responsible for the successful …
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Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
… can modulate the ongoing adaptive CD8+ T cell response to IAV.
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Delivery of antigens to dendritic cells as a platform for a vector-free cancer therapy
Cell based vaccines that activate a patient's immune system via an antigen-specific CD8 T cell response hold much therapeutic potential. One of the greatest challenges in the development of these vaccines is creating antigen presentation by delivery of antigens into the cell cytoplasm. It has been …
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Characterisation of high and low avidity peptide specific CD8+ T cells using immunologic, transcriptomic and proteomic tools
… is the generation of high avidity cytotoxic T cells which can recognise and respond to very low concentration of antigens. This sensitivity of T cells is usually determined by peptide titration ELISpot assays. Even though these assays are generally useful, they are laborious and sample …
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Characterization of anti-tumor T cell specificities to inform engineering of antigen-targeted immunotherapies
… checkpoint blockade has resulted in durable responses for some patients, but others have not seen the same benefits. T cells are essential to the success of many immunotherapies, as their receptors can recognize peptide antigens presented by major histocompatibility complexes (MHCs); …
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