Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"T cell receptors (TCR)"”.
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
<p>Regulatory T-cells (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell …
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Characterizing antigen-specific CD4⁺ T cells using HLA-DR oligomers
T cells are activated by the engagement of their surface T cell receptors (TCR) by antigenic peptide bound to major histocompatibility complex (MHC). The success or failure of this TCR to MHC-peptide interaction determines the specificity of T cell action, and thus plays a central role in proper …
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Stochastic and spatiotemporal effects in T-cell signaling
… and the physical sciences to understand how T cells balance the risks of autoimmunity and infection. (1) What features of proteins do T cells search for that correlate with pathogenicity, distinguishing self from foreign? Two contrasting theories have emerged that attempt to describe T cell …
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Roles of CTCF and YY1 in T Cell Receptor Gene Rearrangement And T Cell Development
<p>Diversity of T cell receptors (TCR) and immunoglobulins (Ig) is generated by V(D)J recombination of antigen receptor (AgR) loci. The Tcra-Tcrd locus is of particular interest because it displays a nested organization of Tcrd and Tcra gene segments and V(D)J recombination follows an intricate …
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Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma
… results, including therapy with adoptive cell transfer (ACT) of T lymphocytes. T cell immunotherapy is highly attractive because T cells have the ability to selectively recognize and destroy malignant neoplastic cells. Although a promising approach, one of the limitations encountered …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
T-cells in the adaptive immune system can recognise a vast space of potentially foreign antigens in a very specific way through their T-cell Receptors (TCR). As the genetic sequence encoding for the TCR is the result of somatic recombination, the TCR sequence varies from T-cell to T-cell, making it …