Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"T cell proliferation"”.
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Active Inhibition of T Cell Proliferation by Monocytes
… well described in their ability to inhibit T cell activation. The most current model is that anti-class II mAb interfere directly with the T cell receptor-major histocompatibility complex crosslinking which is necessary for T cell activation. The anti-CD3 mAb, OKT3, is an MHC class II …
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Monocyte-derived DCs from FIV+ Peripheral Blood Induce Greater CD8+ T Cell Proliferation than those from Uninfected Animals.
North Carolina State University Theses Immunology.
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BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination
… immunity in clinical trials, specific Th1 cells, are typically thought to be protective in TB. However, to date, human mycobacteria-specific Th1 responses have not correlated with risk of TB disease. New approaches are urgently required to identify other factors at play in conferring …
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Intracellular Signaling Networks in the Immune Response: Pathways Activated by Interleukin-2 and Interleukin-4 Receptors and their Roles in T Cell Proliferation
Cells sense and respond to chemical and physical stimuli through signal transduction pathways, which mediate cell proliferation, differentiation, migration, and survival. The cytokines interleukin-2 (IL-2) and interleukin-4 (IL-4) are key regulators of the adaptive immune system, particularly …
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Effects of ovarian steroids on bovine mammary epithelial cells: in vitro and in viro evidence of indirect stimulation of proliferation
… of ovarian steroids on bovine mammary epithelial cell proliferation. In a first study, estrogen (E), progesterone (P), or E+P were administered to prepubertal beef heifers and biopsied mammary parenchyma taken before and following treatment were compared for growth by evaluation of …
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Regulation of macrophage activities by tumor growth: mechanisms of immunosuppression
Macrophages (Mφ) are a major immune cell involved in anti-tumor responses. Mφ activities such as tumor cytotoxicity. presentation of tumor-associated antigens, and stimulation of anti-tumor lymphocytes are all involved in the battle against tumor growth. However, other Mφ activities such as cell …
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Visualizing Dendritic Cells In Vivo
<p>Cell:cell interactions are critical at all stages of the immune response, yet relatively little is known about their dynamics in vivo. We set out to visualize in intact, living lymphoid tissue the physiological role of dendritic cells in tolerance and immunity; this was achieved by intravital …
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Role of Nlc Cells in Murine Models of T Cell-Dependent Responses
NK cells are part of the innate immune system, yet they can also modulate the acquired immune response. Activated NK cells, for instance, can increase antigen specific IgG2a production in response to T independent responses, mostly through IFN-gamma secretion. Previous experiments examining the …
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Modulation of immune responses by human paraininfluenza virus
… infection generated potent and mature dendritic cells (DCs). However, unlike influenza A generated DCs, allogeneic human mixed leukocytes (MLR) failed to proliferate to HPIV3 generated DCs. Conversely pur3ed CD3+T cells were capable of expanding to these DCs. Further investigation revealed that …
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Effects of Growth Hormone and Insulin-Like Growth Factor-I on Milk Protein Gene Expression and Nutrient Uptake and Cell Proliferation in Clonal Bovine Mammary Epithelial Cells
… a major mediator of GH action in vivo, on cell proliferation, nutrient transport, and milk protein gene expression in bovine mammary epithelial cell line MAC-T cells were determined. GH increased (P < 0.01) expression of four major milk protein genes in MAC-T cells transfected with GHR …
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Dysregulated B Cells in Relapsing Remitting Multiple Sclerosis and Their Impact on T-Cell Function
… of the central nervous system. The role of B cells in the pathoetiology of MS is substantiated by cell depletion therapies but is not well understood. We hypothesized that B cells from MS patients would secrete more pro-inflammatory cytokines and support T cell responses to self-antigens and …
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Analysis of trafficking dynamics and cellular response in the interleukin-2 ligand/receptor system
… primarily to its central role in potentiating cell-based immunity. The effects of IL-2 on its cellular targets are mediated solely through interaction with one or more forms of the IL-2 receptor (IL- 2R). The overall goal of this thesis is to quantitatively characterize IL-2/IL-2R interactions …
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The effect of manipulating apoptotic cell uptake on their immunogenicity
… system to differentiate between apoptotic tumour cells and cells rendered apoptotic as part of homeostasis prevents a successful response being mounted against tumours. Apoptotic cells are cleared rapidly by professional phagocytes thus preventing the release of potentially inflammatory or …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
Antigen presenting cells (APCs) perform the essential task of integrating responses between the innate and adaptive immune system. Several approaches have been undertaken to manipulate the effects of APCs for therapeutic purposes. Panax notoginseng is a medicinal herb that is purported to possess a …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
Antigen presenting cells (APCs) perform the essential task of integrating responses between the innate and adaptive immune system. Several approaches have been undertaken to manipulate the effects of APCs for therapeutic purposes. Panax notoginseng is a medicinal herb that is purported to possess a …
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The impact of myeloid derived suppressor cells on vaccine immunogenicity in South African HIV-infected and uninfected mothers and their infants
… We hypothesized that myeloid-derived suppressor cells (MDSC) that might be induced during gestation, would persist at birth leading to active suppression of infant-immune responses. OBJECTIVE: We evaluated the ontogeny of MDSC and the effect of MDSC on vaccine immunogenicity during early life in …
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Astrocytes modulate microglial phenotype and dendritic cell-like properties
Microglia are the resident immune cells of the CNS. In the healthy CNS, they express negligible levels of MHC II molecules as well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in …
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Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
… affected the quantity and quality of T cell response and subsequent anti‐tumor efficacy. Here we describe L‐tyrosine amino acid‐based microparticles as a novel peptide vaccine adjuvant for the induction of tumor‐specific T cells. L‐tyrosine microparticles did not induce inflammasome …
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Ctla-4 transcriptional activation: regulation of induced expression
… T-lymphocyte antigen 4 (CTLA-4) is a T cell surface protein that is homologous to CD28 and binds to the B7 family of ligands. Unlike CD28, CTLA-4 interaction transmits a negative signal in T cells, leading to suppression of proliferation. CTLA-4 is constitutively expressed on regulatory …
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