Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"T cell migration"”.
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Follicular Regulatory T cell migration and differentiation
… response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through …
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Quantitative methods for multiplexed cellular engineering and directed evolution
… particular, it has been effective at controlling cells, designing proteins, determining targets for gene therapy, and developing small molecule drugs. This thesis contributes to cellular engineering and multiplexed screening in three projects. First, this thesis introduces a sequence-aware …
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Multi-scale models of T cell activation
… adaptive immune response: the activation of T cells. The specific objectives are: 1) develop efficient and versatile computational frameworks to study multi-scale biological systems in silico; 2) obtain mechanistic insights into how T cells are triggered in vivo. The first problem investigated …
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
… Integrins are versatile proteins and mediate T cell migration and trafficking by binding to ECM or other cells, as well as initiating intracellular signaling cascades promoting survival or activation. The mitogen activated-protein kinase (MAPK) pathway is known to be downstream from integrins …
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Phosphorylation Regulation of T-Lymphocyte Migration
… of external environmental cues to intracellular physical changes in leukocytes requires a cascade of receptors, signal transducers, and mechanical effectors. My doctoral research focused on using T-cells as a model to study the unique cellular process of how signal transducers interact …
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Regulation of LFA-1 on T cells by phosphoinositide signalling
… Antigen 1 (LFA-1) is the major integrin in T cells and binds Intercellular Adhesion Molecule 1 and 2 (ICAM-1 and ICAM-2) expressed on endothelial cells and antigen presenting cells. LFA-1 affinity for ICAM is increased following chemokine and T cell receptor (TCR) engagement by inside-out …
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Enhancement of Hiv Persistence By Adipose Tissue
… for HIV eradication is the persistence of cellular and anatomic viral reservoirs. The primary cellular reservoirs for HIV, memory CD4 T cells and macrophages, traffic into various tissues where most viral replication occurs, or in the case of virally-suppressed antiretroviral-treated …
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THE EFFECT OF CONFINEMENT ON T-LYMPHOCYTE UPSTREAM MIGRATION UNDER SHEAR FLOW
… evolved to perform this function. One step is migration on the endothelium. CD4+ T-lymphocytes migrate upstream on intracellular adhesion molecule-1 (ICAM-1). In this thesis, we explore the potential of this upstream migration to direct T cells confined within microcontact printed and …
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T cell Immunomodulation in the Lymph Node for Inhibition of Load-Induced Osteoarthritis
… approach targeting specific immune cells. However, the crosstalk of joint pathology with local lymph nodes in OA is poorly understood. We characterized the T cell immune response in local lymph nodes following the in vivo mechanical loading of joints. First, we analyzed the change in …