Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"T cell memory"”.
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Hedgehog signalling in CD8+ T cell memory
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Defining mRNA-generated T cell memory in respiratory viral infection
T cell immune memory provides protective effector mechanisms to restrict pathogen growth upon secondary infection, although the ability of T cells generated by novel mRNA-LNP vaccines to restrict viral infection in currently unknown. To address this, we studied antigen specific T cell memory …
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A novel model system for the study of anti-tumour T-cell memory
… the fate and requirements of longterm persisting memory T-cells can be monitored. Anti-tumour immune peritoneal exudate cells (iPEC) were produced by injecting a subtumorigenic dose of the highly metastatic, ß-gal<sup>+</sup> T-Iymphoma into the ear pinna of syngeneic DBN2 mice, followed by an …
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HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity
… or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into …
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An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines
… of the current study was to characterise the T cell memory phenotype distribution in peripheral mononuclear cells (PBMCs) isolated from Chacma baboons vaccinated with SAAVI MVA-C/VLP and DNA/VLP prime-boost vaccination regimens by flow cytometry.
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… upon stimulation, which can modulate immune cell function primarily through the beta2-adrenergic receptor (ADRB2). Our previous work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… pathway, is lowly expressed in some stem cell niches and overexpressed in multiple cancers, including pre-B acute lymphoblastic leukaemia (pre-B ALL), hepatocellular carcinoma (HCC) and colorectal cancer (CRC). LGR5 has thus emerged as a promising therapeutic target and has spurred the …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
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Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity
… IL-15 to augment the therapeutic potential of T cells expressing chimeric antigen receptor: Maintaining memory potential, persistence, and antitumor activity</strong></p> <p>Adoptive immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell malignancies, by …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… immunoregulatory pathway for modulating CD8+ T cell responses. This pathway has become an important therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves outcomes. However, it remains unclear how PD-1 pathway signals …
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T Cell Immunosurveillance in Pancreatic Ductal Adenocarcinoma
ABSTRACT T CELL IMMUNOSURVEILLANCE IN PANCREATIC DUCTAL ADENOCARCINOMA Rebecca A. Evans Robert H. Vonderheide The prevailing theory of cancer immune surveillance, as understood from carcinogen-driven mouse models of highly mutated tumors, states that T cell-mediated immune pressure drives a …
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Clonotypic Analysis of CMV-Specific CD4+ T Cells in Human and Nonhuman Primates
… a host via mechanisms of immune evasion. CD4+ T cells are known to play a role in maintaining life-long immunity against CMV; however, the cellular requirements for establishing and maintaining protection against CMV disease have not been characterized. The objective of this work was to …
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Defining the human immune signature following infection with Crimean-Congo haemorrhagic fever virus
… for antibody, serum circulating biomarker and T-cell memory responses. The studies demonstrated that neither IgM nor IgG antibodies were raised to CCHFV antigens in patients with severe disease despite each patient surviving for long enough such that a suitable immune response could have been …
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Regulation of Wnt signalling in ovarian cancer and immune cells
… regulated pathway involved in embryogenesis, cell polarity, and migration. Dysregulation of Wnt signalling is associated with abnormal cellular growth contributing to cancer formation. Especially in colorectal cancer (CRC) mutations in the Wnt pathway that enhance signalling are driving forces …
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Immunological markers of protective immune reconstitution in HIV infected persons sensitised by Mycobacterium tuberculosis
… in the form of transcriptomic, soluble or cellular biomarkers. This thesis focuses on characterising Mtb-specific reconstituting CD4 T cells as well as soluble and transcriptomic markers in HIV infected persons, sensitised by Mtb, by analysing samples collected longitudinally during 6 …
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Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy
… the virus induces multiple defects in immune cells, altering their functional ability to efficiently control HIV itself and other infections. Whilst the widespread implementation of antiretroviral therapy (ART) has led to reduced morbidity and mortality in most HIV-infected individuals having …
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CD4 and CD8 T-cell responses to acellular pertussis and rotavirus vaccination in breast-fed HIV exposed, uninfected infants
… attenuated rotaviral vaccine (Rotarix) and acellular Pertussis (aP), were analyzed in HEU infants, with specific focus on T-cell responses to Rotarix and aP, due to the current lack of published data on T-cell responses. Additionally, the influence of feeding mode, that is breast or formula …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
Regulatory T (Treg) cells suppress CD4+ T cell responses during homeostasis and inflammation to prevent autoimmunity and other immune disorders. Although the transcriptional and epigenetic programs impacting Treg cell function have been extensively studied, the signaling and metabolic pathways …