Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"T cell line"”.
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Biotransformation studies on tobacco cembranoids using plant cell cultures
… studies on tobacco cembranoids using the plant cell culture lines coded as TRP4a and T-43-T which are derived from Tripterygium wilfordii, an important Chinese herbal plant, and Nicotiana sylvestris, respectively. The studies are divided into three parts: 1) Biotransformation of the diols 1 and …
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Development of a Modular Anti-HIV Transducer Protein
… of the virus in a small percentage of infected cells. New approaches to eradicate the HIV infection are mainly targeting the latent reservoir cells. The combinations of the drugs that activate latently infected cells and subsequently kill them are getting attention. Here, we proposed the design …
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Characterization of the Tetraspanin protein Tspan18
… Tetraspanins regulate diverse processes such as cell signalling and fusion, intracellular trafficking, viral infection and cancer. The primary aim of this thesis was to study a previously uncharacterized tetraspanin, Tspan18. Unlike other tetraspanins, over-expression of Tspan18 in lymphocyte …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
… In the second part, it was shown that a T-cell line migrates chemotactically to IL-6. Probably the migration is caused by a cross talk between the IL-6 und the Integrin pathways.
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Xenogeneic transplantation of immortalized bovine mammary epithelial cells
… use of an immortalized bovine mammary epithelial cell line as a starting material for xenogeneic transplantation into the mammary glands of immunocompetent recipients. PSG-5 cells (a clonal derivative of the MAC-T cell line engineered to express ovine IGF-I ) were transplanted into the cleared …
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Intracellular Signaling Networks in the Immune Response: Pathways Activated by Interleukin-2 and Interleukin-4 Receptors and their Roles in T Cell Proliferation
Cells sense and respond to chemical and physical stimuli through signal transduction pathways, which mediate cell proliferation, differentiation, migration, and survival. The cytokines interleukin-2 (IL-2) and interleukin-4 (IL-4) are key regulators of the adaptive immune system, particularly …
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Die Bedeutung von Zinkionen für mononucleäre Leukocyten
… important influences of zinc on mononuclear cells were examined.For the first time, a direct stimulation of cells by zinc could be shown, which was dependent on zinc concentration and could not be induced by other cations. Even in physiological doses, zinc interacts significantly with …
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Molecular Characterization of the Human Alloimmune Response
… translate in vivo into graft rejection of stem cell and solid organ transplants and to graft versus host disease (GvHD) in recipients of allogeneic stem cell transplants. Defining the clonal T cell responses elicited in an MLR between two individuals is complicated by the multiplicity of T cell …
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Molecular Characterization of the Human Alloimmune Response
… translate in vivo into graft rejection of stem cell and solid organ transplants and to graft versus host disease (GvHD) in recipients of allogeneic stem cell transplants. Defining the clonal T cell responses elicited in an MLR between two individuals is complicated by the multiplicity of T cell …
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Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
… in a range of biological processes including cell signalling, adhesion, intracellular trafficking, cell-cell fusion and viral entry. The tetraspanin CD37 was recently shown to negatively regulate the C-type lectin-like receptor dectin-1, which is essential for innate immune responses to fungal …
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Identification and characterization of a chicken major histocompatibility complex class II[beta] gene promoter
… involved in antigen presentation to helper T cells, a key step in initiating immune responses. The regulation of class II gene expression has been extensively studied in mammals. Such studies have been lacking in the avian species, despite the well-established association of the avian MHC with …
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The role of the adapter protein TSAd in T cell activation
Introduction: T cells are a part of the adaptive immune system, which is designed to attack pathogens in the body. T cells recognize antigen presented by HLA molecules on the surface of antigen presenting cells (APC) through their T cell receptor. Conjugation formation between T cells and APC turns …
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Detecting and defining immunity to human cytomegalovirus (HCMV) in health; combining QuantiFERON®-CMV and flow cytometry
… Following allogeneic haematopoietic stem cell transplant (allo-HSCT), reactivation of CMV can cause severe morbidity and mortality. CMV DNA monitoring by polymerase chain reaction (PCR) and timely administration of pre-emptive antiviral treatment in the case of reactivation are vital to …
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Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis.
… contribute to the recruitment of immune cells into the CNS, and are expressed by astrocytes, the most abundant cell type in the CNS, and endothelial cells. CCL2 and CXCL10 are chemokines expressed in MS lesions, which are thought to be pivotal in chemoattraction of T cells and monocytes …
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The Elucidation of the Mechanisms of CD8+ T Cell-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication
… of 3 key components, the virus, the effector cell and the target cell, each of which contribute to noncytolytic suppression. During the course of CNAR, the effector cells express antiviral factors that induce intracellular events in the target cell resulting in host-pathogen interactions that …
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Recognition of hepatitis B epitopes by T cell receptors and T cell receptor-like antibodies
T cells play a vital role in the adaptive immune response against viral infections. Virus-specific T cells recognize infected cells through a heterodimeric surface receptor known as the αβ T cell receptor (TCR). The TCR recognizes a peptide epitope presented by a product of the major …
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Der Einfluß von Virusinfektion und Impfung auf autoreaktive T-Lymphozyten bei der Multiplen Sklerose
… und Heterogenität der Subpopulatio-nen sind monolineare Erklärungsansätze bislang zum Scheitern verurteilt gewesen. Aber aus dem Fehlen eines Beweises kann nicht der Beweis für das Fehlen eines Zusammen-hangs zwischen Virusinfektionen und Autoimmunreaktionen geschlossen werden.
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Regulation of Bovine Mammary Epithelial Cell Response by Autocrine IGF-I and by Collagen I
… factor-I (IGF-I) signaling in mammary epithelial cells may be modified or interrupted by modifications in the cellular environment may lead to 1) methods to increase the growth and proliferation of normal mammary epithelial cells for an increase in the amount of milk produced on a per animal basis …