Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"T cell landscape"”.
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Interrogating the functional adaptions of Tumour-draining lymph nodes (TDLNs) and the subsequent impact of checkpoint inhibition
… model I identified significant changes in the T cell landscape of TDLNs. While the CD8-mediated immune response is effectively suppressed in TDLNs, the CD4 compartment undergoes dramatic alterations. Most notably, regulatory T cells (Tregs) expand and become more active, upregulating suppressive …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… is aimed at reinvigorating local cytotoxic T cells, however the rate of immunotherapy failure in non-small cell lung cancer (NSCLC) is as high as 80%. An improved mechanistic understanding of immunosuppressive pathways in NSCLC is important to develop novel diagnostic and therapeutic …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… approaches. To this end, we combined single-cell transcriptomic with paired V(D)J profiling to generate a multi-compartmental innate immune map of synchronous CRC and matched sCRLM, together with circulating blood samples. Our analyses revealed that Tumor-Associated Macrophages (TAMs) and …