Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"T cell immunotherapy"”.
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Enhancing T cell immunotherapy through dosing of memory transcription factors
T cell therapies hold promise for treating solid tumours, but their efficacy is limited by poor persistence of transferred cells. Previous strategies to enhance persistence often relied on enforcing constitutively activated, and hence potentially toxic or oncogenic, T cell states. In contrast, …
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Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma
… results, including therapy with adoptive cell transfer (ACT) of T lymphocytes. T cell immunotherapy is highly attractive because T cells have the ability to selectively recognize and destroy malignant neoplastic cells. Although a promising approach, one of the limitations encountered …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
… advances in chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Myeloid cells are actively recruited to the tumor microenvironment (TME), where tumor associated macrophages (TAMs) are often the most …
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Cd56-Specific T Cells: Using Genetically Engineered T Cells to Redirect Specificity to A T Cell Expressed Antigen
… for applying CARs to new targets. Using T cells to target a T cell expressed antigen, such as CD56, seems counterintuitive in that the T cells would be susceptible to self-targeting a.k.a. fratricide. However, we expand CD56-specific CAR<sup>+</sup> T cells that co-express the CD56 antigen. …
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Cooperativity: Physiologic Cornerstone and Emerging Therapeutic Design Principle
The content of this work is based on the previously published articles that are cited below.
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Tsyn-Seq: A T Cell Synapse-Based Antigen Identification Platform
… histocompatibility complex targets of T-cell receptors (TCRs) are not yet universally available. We present a new antigen screening method, the T-synapse (Tsyn) reporter system, which includes antigen-presenting cells (APCs) with a Fas-inducible NF-κB reporter and T cells with a nuclear …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… pathway, is lowly expressed in some stem cell niches and overexpressed in multiple cancers, including pre-B acute lymphoblastic leukaemia (pre-B ALL), hepatocellular carcinoma (HCC) and colorectal cancer (CRC). LGR5 has thus emerged as a promising therapeutic target and has spurred the …