Global ETD Search
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Showing 1 to 2 of 2 for “"T cell immunoglobulin- and mucin domain-3 (Tim-3)"”.
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Identification of Regulatory DNA Region and Transcription Factors Important for TIM-3 Transcription
TIM-3는 T 세포 immunoglobulin- and mucin-domain-containing molecules (TIMs) family의 하나로서 보조 T 세포 1형에서 특이적으로 발현하는 분자로 발견되었다. 이 분자는 비만세포에서도 발현이 되며 TGF-β에 의해 발현이 증가한다고 알려졌으나 분자생물학적인 발현기작에 대해서는 연구되지 않았다. 본 연구에서는 TIM-3의 분자생물학적인 발현조절기작을 밝히기 위해 TIM-3 upstream DNA와 intron 1과 2를 각각 포함하는 luciferase reporter …
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The Effect of Tim-3-Ig on Tumor Growth
Tim-3, a member of the novel TIM (T cell immunoglobulin- and mucin-containing-domain) family of molecules, is the first molecule identified to be specifically expressed on CD4+ Th1 and not on Th2 cells. Tim-3 negatively regulates Th1 immunity and induces tolerance, but it's function has not been …