Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"T cell homeostasis"”.
-
Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function
… unique functional attributes possessed by T cells are initiated after stimulation via their T cell receptor (TCR). Due to the T cell's integral role in immune function, the regulation of signaling events downstream of the TCR have been, and continue to be, an area of intense research. An …
-
Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… immune responses requires a large naive T-cell population with a wide diversity of target specificity. Naive CD8⁺ T-cells depend on T-Cell Receptor (TCR) and ye cytokine signals for their homeostatic survival and proliferation, but differences in sensitivity to these homeostatic signals …
-
INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… to eradicate the virus or fully restore immune homeostasis. This study explores two critical aspects of HIV management: (i) the impact of early cART initiation during PHI on inflammation, immune activation, and microbial translocation, and (ii) the effects of innovative therapeutic strategies, …
-
Regulation of LFA-1 on T cells by phosphoinositide signalling
… Antigen 1 (LFA-1) is the major integrin in T cells and binds Intercellular Adhesion Molecule 1 and 2 (ICAM-1 and ICAM-2) expressed on endothelial cells and antigen presenting cells. LFA-1 affinity for ICAM is increased following chemokine and T cell receptor (TCR) engagement by inside-out …
-
Impact of Thymectomy on the Peripheral T Cell Pool in the Context of SIV Infection
… is the primary lymphoid organ responsible for T cell production. It is of particular interest in the context of human immunodeficiency virus (HIV)-1 infection, in which the progressive loss of CD4+ T cells leads to immunodeficiency and opportunistic infection. CD4+ T cell loss is thought to …
-
Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
… inhibits the actions of proinflammatory Th-17 cells. We have previously described decreased CD103+ DCs numbers in the intestinal compartments of RARα-deficient mice (RARαvillin mice). We sought to generate an experimental system to identify signaling pathway(s) or mechanism(s) that might be …
-
Development of a Human Immune System from Hematopoietic Stem Cells in a Human/Mouse Xenogeneic Model
T cells play a central role in the development of immune responses. Patients lacking T cells due to genetic defects such as DiGeorge or Nezelof's syndrome and individuals infected with the human immunodeficiency virus are highly susceptible to infections and cancers. The lack of adequate in vivo …
-
Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… plays an essential role in numerous cell functions, including apoptosis and the induction of immune responses. Ariadne 2 is a RING finger E3 ligase and is part of the highly conserved RBR (RING-B-Box-RING) superfamily, however, little is known of its function in mammalian systems. To …
-
Distinct Patterns of Ccr5 Versus Alternative Coreceptor Dependence in Non-Natural Host Versus Natural Host Simmian Immunodeficiency Virus Infection
… plasma viral loads without widespread CD4+ T cell loss. By contrast, non-natural host rhesus macaques experimentally infected with related SIV exhibit high viral loads but display subsequent CD4+ T cell loss and progression to AIDS, analogous to the effects of HIV-1 infection in humans. …
-
The Functions of Autophagy Genes in Lymphocytes and Osteoclasts
… herein autophagy) is a process by which cells degrade long-lived proteins and organelles. The autophagy pathway and autophagy genes have been implicated in many functions in the cell such as protecting against metabolic stress, degrading damaged organelles, and regulating vesicular …
-
Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… immunological processes such as T cell homeostasis and immune-regulation.<br/>While the biological functions of STAT5 are well established from murine genetic<br/>studies, the downstream mediators of these proteins are poorly understood. In this study,<br/>an improved chromatin …
-
Genetic Loci Contributing to Spontaneous Autoimmune Diabetes
… as in FACS sorted thymocytes and peripheral T-cells stained with CD4 and CD8 monoclonal antibodies showed a reduction in expression of four out of five Gimap genes located within the Iddm39 interval, in addition to Gimap5, in DR.lyp/lyp spleen and mesenteric lymph nodes (MLN) when compared to …