Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"T cell help"”.
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The Role of CD4+ T cells in the CD8+ T cell Response to Vaccinia Viral Infection
<p>The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens remains incompletely defined. The primary CD8 T response to infections was initially thought to be largely independent of CD4 T cells, but it is not clear why some primary, pathogen-specific CD8 T …
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Selection Dynamics in the Germinal Center During Antibody Affinity Maturation
… upon infection or immunization. High affinity B cells are selectively expanded in the GC by iterative rounds of migration between a zone of hypermutation and proliferation (the dark zone, or DZ) and a zone of selection (the light zone, or LZ). The mechanism whereby somatic antibody mutants are …
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B Cell Receptor Signalng in Germinal Centers
<p>Germinal centers (GC) are sites of B cell clonal expansion, diversification, and antibody affinity selection. This process is limited and directed by T follicular helper cells that provide helper signals to B cells that endocytose, process, and present cognate antigens in proportion to receptor …
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HIV prophylaxis: an essential role for T cells and adjuvants in recombinant mucosal Lactobacillus acidophilus vaccines
… and in CD40L-/- mice to observe if T cell help was necessary. Some BALB/c animals were also placed on a modified diet supplemented with prebiotic rice bran to observe any influence on vaccine immunogenicity. Resulting antibody responses and interleukin-17 levels were measured by ELISA, …
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Recording Cellular Interactions in Germinal Centers and Beyond
<p>In multicellular organisms, each cell has a distinct identity characterized by unique transcriptional and chromatin accessibility profiles. However, to truly understand the organization and function of such systems, it is not enough to merely characterize individual components; we must also …
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Identification of candidate tumour antigen peptides with immunogenic potential for use in cancer immunotherapy
It is now understood that CD4+ T cells play a central role in antitumour immunity; they are important in the priming of CTL and can augment cytotoxicity; they are also responsible for enhancing antitumour responses via indirect mechanisms such as recruitment of accessory cells to the tumour site …
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Recall Germinal Center and Antibody Responses
… response is a result of the recall of memory B cells (MBCs) that have undergone clonal expansion and affinity maturation in germinal centers(GCs) during the primary response. Upon antigen re-encounter ("boosting"), MBCs, aided by enhanced help from memory T cells, efficiently differentiate into …
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An alternative B cell development program
Two major types of B cells, the antibody-producing cells of the immune system, are classically distinguished in the spleen: marginal zone (MZ) and follicular (FO). In addition, FO B cells are subdivided into FO I and FO II cells, based on the amount of surface IgM. MZ B cells, which surround the …
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TFR Cells Suppress Gut Commensal-Specific IgA Via IL-10
… of IgAcoated gut commensals is generated via T cell-independent pathways. However, highaffinity, antigen-specific IgA Abs are produced through T cell help in the germinal centers of gut-associated lymphoid tissues. Through this pathway, T follicular helper (TFH) cells drive affinity maturation …
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Enhancing T-Cell Responses to Vaccination of HIV-1 infected Subjects on Antiretroviral Therapy
… with HIV-1. Even with the benefits to CD4+ cell counts, decrease in viremia and inflammatory biomarkers, HIV-1 infected individuals continue to exhibit functional issues in their T-cell immune responses to recall antigens and vaccines. Additionally, researchers believe that T-cell mediated …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… system for processing and presentation to CD4+ T cells. Experiments conducted by Michael Bevan in the 1970s demonstrated that exogenous antigen can also enter the MHC class I system and cross-prime CD8+ T cells; the process by which antigen presentation occurs in this context is termed …
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Single chain MHC trimer-based DNA vaccines for pathogen protection
CD8+ T cells play a major role in controlling infection and disease progression in many infectious diseases. Upon infection, antigen-specific CD8+ T cells are generated and mainly through their cytotoxic activity remove infected cells, therefore, pathogens. Ongoing research has identified antigenic …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… attacks self-antigens and destroys body’s own cells and tissues. Chronic autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and the primary Sjögren’s syndrome (pSS) decrease life quality of patients and can lead to life threatening events such as lupus …
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B cell signalling in mechanisms of central and peripheral tolerance
… system to prevent autoimmunity. Hence during B cell development, a number of central and peripheral developmental checkpoints ensure the deletion of self-reactive B cells and selection of tolerant B cells. For example, antigen-driven ligation of the B cell receptor (BCR) on immature B cells …