Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"T cell development"”.
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Aspects of T cell development contributing to autoimmunity.
… breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. The work presented in this thesis was aiming at unravelling some of …
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The Influence of the Microbiota on T Cell Development
T cell development occurs in the thymus and is a complex and well-regulated process. Errors during this process can lead to immunodeficiencies and autoimmunity. This project will also look at recent thymic emigrants (RTEs). RTEs are the most immature subset and have been shown to have distinct …
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The roles of Cabin1 and Left1 in T cell development
… 2 (MEF2) through the C-terminal region. In cell lines, these interactions inhibit calcineurin activity following TCR signaling and transcriptional activation of Nur77 by MEF2. The role of these interactions in vivo was investigated using a mutant mouse strain that expresses a truncated Cabin …
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Control of chromatin accessibility during CD4+ T cell development and activation
T cells coordinate immune functions by differentiating into highly specialised cellular lineages that either promote or suppress immune reactions. Whereas effector T (Teff) cells drive immune activation and promote clearance of infections and cancer, regulatory T (Treg) cells suppress their …
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Characterization of Stress Responsive MicroRNAs and Their Roles in T Cell Development
… and adaptive immune responses. Immature αβ T cells developing in the thymus are particularly sensitive to stress, with infections and/or exposure to lipopolysaccharide or glucocorticoids eliciting a rapid apoptotic program. MicroRNAs (miRs) are short, non-coding RNAs that play critical roles …
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Characterizing the role of thymic interferon in T cell development and selection
… induced during infections, where they protect cells against viral infection and activate immune cells. Curiously, both type I and type III IFNs were reported to be produced at low levels in the thymus in the absence of infection – the site of T cell development and a crucial organ for immune …
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Forkhead Transcription Factors Foxp1 and Foxp4 Regulate T Cell Development and Function
Transcription factors regulate T cell fates at every stage of development and differentiation. Members of the FoxP family of Forkhead transcription factors are essential for normal T lineage development; Foxp3 is required for regulatory T cell generation and function, and Foxp1 is necessary for the …
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IDENTIFYING, CHARACTERIZING AND VERIFYING NOVEL C-MAF FUNCTIONS IN T CELL DEVELOPMENT AND APOPTOSIS
… and tightly controlled activities of T cells offer a unique test case for understanding cell regulation. This study is to investigate the mechanisms underlying c-Maf mediated control of developing and mature T cells. c-Maf, a basic leucine zipper transcription factor, is well known for …
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Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
… encounter with antigen. This can lead to the development of debilitating and potentially life-threatening autoimmune diseases such as type-1 diabetes, rheumatoid arthritis and multiple sclerosis. Regulatory T cells (Tregs) are a subset of CD4+ T cells that express the lineage-specific …
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
… essential role of classical MHC molecules in T cell development as well as the proteasome role in antigen processing for MHC-mediated antigen presentation to T cells is well established. However, the contribution of nonclassical MHC molecules, the signals evoked by the MHC-TCR interactions, the …
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Roles of CTCF and YY1 in T Cell Receptor Gene Rearrangement And T Cell Development
<p>Diversity of T cell receptors (TCR) and immunoglobulins (Ig) is generated by V(D)J recombination of antigen receptor (AgR) loci. The Tcra-Tcrd locus is of particular interest because it displays a nested organization of Tcrd and Tcra gene segments and V(D)J recombination follows an intricate …
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The dependence of CD4 T cell development and activation on the kinetics of the TCR:pMHC interaction
<p>The T cell is a critical player in the adaptive immune response. T cells function by stimulating antibody production by B cells, secreting cytokines to attract other immune cells, regulating the response of other T cells, and directly killing infected or damaged targets. The role of the adaptive …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
T cell development is regulated by signals generated in the interactions between developing thymocytes and the thymic stroma. Using fetal thymus organ culture (FTOC) as a model of T cell development, we investigated the ability of two potent signal modulators to influence this process. These …
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BACH2 orchestrates thymic T cell differentiation and functional programming
… is a highly specialised organ required for T cell development and establishing immunological tolerance. It is tasked with maximising the number of foreign antigens which can be recognised by the T cell receptor (TCR) repertoire in order to protect from infection. Simultaneously, the thymus …
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Developmental Regulation of the Murine CD4 Gene
… glycoprotein that plays an important role in T cell development and activation. An extensive analysis of the CD4 locus identified potential transcriptional control elements located 5' of the promoter and within the first intron. Since the molecular mechanism for the control of CD4 expression …
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Identification and Characterization of Control Elements within the Murine CD4 Gene
… gene expression is essential for T lymphocyte development. Since the molecular mechanism for the control of CD4 gene expression during T cell development had not been elucidated, a study of the factors that control CD4 gene expression may lead to further. Toward these goals, we have made a …
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