Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"T cell adhesion"”.
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
… resident cholesterol is a key regulator of T cell immunity as it stabilises immune synapses, thus supporting effector T cell function. Recent publications suggest that increasing plasma membrane cholesterol content boosts anti-viral and anti-cancer immunity in T cells. Inhibition of …
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Regulation of LFA-1 on T cells by phosphoinositide signalling
… Antigen 1 (LFA-1) is the major integrin in T cells and binds Intercellular Adhesion Molecule 1 and 2 (ICAM-1 and ICAM-2) expressed on endothelial cells and antigen presenting cells. LFA-1 affinity for ICAM is increased following chemokine and T cell receptor (TCR) engagement by inside-out …
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
… with the migration and accumulation of T-ALL cells in the tissues. Rap and Rho family GTPases play key roles in T cell adhesion and migration and are often involved in cancer progression. Most of these proteins are post-translationally isoprenylated to facilitate their anchorage to membranes, …
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HTLV-1 bZIP FACTOR ACTIVATES MYOFERLIN EXPRESSION TO FACILITATE HTLV-1 INFECTION AND MIGRATION OF INFECTED T-CELLS
Human T-cell Leukemia Virus type 1 (HTLV-1) is a complex retrovirus responsible for diseases such as Adult T-cell Leukemia (ATL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The viral protein HBZ is consistently expressed in infected individuals and plays a crucial role …
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
<p>The regulation of integrin-mediated adhesion is of vital importance to adaptive and innate immunity. Integrins are versatile proteins and mediate T cell migration and trafficking by binding to ECM or other cells, as well as initiating intracellular signaling cascades promoting survival or …