Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1553 for “"T cell"”.
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The Characterization of T-Cell Manufacturing For Adoptive T-Cell Therapies
<p>Adoptive T-cell therapy using genetically modified T cells has emerged as a potential therapeutic option for several malignancies. Central to the production of the cellular therapy is the manufacturing using a stimulation, genetic engineering, and expansion methodology. Within this framework, …
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… and objectives: A distinct subset of T helper cells, named follicular helper T- (TFH) cells, have been recently described. The TFH-cells can be identified on the basis of the expression of several markers including: the chemokine CXCL13; the costimulatory molecules PD-1 and inducible …
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The Role of T Cell Receptor: Peptide MHC Affinity in T Cell Activation
… without the need for stabilization, using a T cell display system. T cells bearing the newly isolated TCR bound pepMHC and were activated in the absence of co-receptor. This result demonstrates the feasibility of engineering full-length TCRs on the surface of T cells using a retroviral vector.
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Regulated T cell pre-mRNA splicing as genetic marker of T cell suppression
Includes abstract. Includes bibliographical references.
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the …
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
… T lymphocytes (CTLs) are potent effector cells of the immune system, capable of directly lysing neoplastic and infected cells. The Hedgehog (Hh) signalling pathway - a critical regulator of embryonic development and adult tissue maintenance - is induced in CTLs following TCR stimulation …
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T Cell Exhaustion in Glioblastoma
… of immunotherapy which seeks to perpetuate T cell activity by blocking inhibitory immune checkpoints. This strategy has gained FDA approval in several solid tumors, yet has failed in GBM. Severe T cell dysfunction such as T cell exhaustion is a known contributor to failures of immune …
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T cell mediated combination immunotherapy
… cytokine support, and comprehensive adoptive T cell transfer make up the broad field of immunotherapeutics. Due to the naturally complex interactions inherent in the immune system, there are many options for therapeutic intervention, however, this same complexity makes it extremely difficult to …
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Roles of CTCF and YY1 in T Cell Receptor Gene Rearrangement And T Cell Development
<p>Diversity of T cell receptors (TCR) and immunoglobulins (Ig) is generated by V(D)J recombination of antigen receptor (AgR) loci. The Tcra-Tcrd locus is of particular interest because it displays a nested organization of Tcrd and Tcra gene segments and V(D)J recombination follows an intricate …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… have seen important advances in the area of T cell-based therapy for human malignancies. Epstein Barr virus-associated tumours like Hodgkin’s Lymphoma provide important models in this field. If a T cell-based therapy is to be effective however, T cells must be capable of trafficking to the …
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Recognition of hepatitis B epitopes by T cell receptors and T cell receptor-like antibodies
T cells play a vital role in the adaptive immune response against viral infections. Virus-specific T cells recognize infected cells through a heterodimeric surface receptor known as the αβ T cell receptor (TCR). The TCR recognizes a peptide epitope presented by a product of the major …
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On Thymic Regulatory T-Cell Ontogeny
<p>Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), …
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RNA Dynamics in T Cell Activation
<p>Eukaryotic cells employ multiple posttranscriptional mechanisms to fine tune gene expression programs in response to external signals. Regulation of messenger RNA and microRNA by RNA-binding proteins is critical to the control of this process. Hence, disruptions of RNA regulatory processes …
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Regulation of T-cell signaling networks
… of how biology carries information within cells, it is not sufficient to look at individual protein or gene interactions, but to understand these networks of interactions as a whole. The goal of this thesis is to understand various aspects of how cells in general and T-cells in particular …
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Stochastic processes in T-cell signaling
T cells are orchestrators for adaptive immunity. Antigen recognition by T cells is mediated by the interactions between T-cell receptors (TCRs) and peptide-MHC (pMHC) molecules. How T cells can translate stimulatory external cues (e.g., TCRpMHC interactions where the peptides are derived from …
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The Use of High-Affinity T Cell Receptors to Study Specificity in the 2C T Cell System
… virus or tumor antigens (peptide-MHC) on the cell surface. In addition, the TCRs would provide a useful probe for tracking the processing and presentation of specific antigens. Chapter 6 discusses the development of soluble single-chain TCRs with enhanced properties, such as increased avidity …
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Characterization of a single-chain anti-T cell receptor antibody and a single-chain T cell receptor
The T cell receptor (TCR) is a cell surface protein that specifically binds to a foreign antigen on the surface of another cell. The TCR is made up of two disulfide-linked chains (called $\alpha$ and $\beta$) each containing a variable and a constant domain. The tertiary structure and binding …
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Pharmacological regulators of T cell calcium stores
<p>Calcium is a crucial intracellular messenger controlling a plethora of important intracellular events. Elevated [Ca<sup>2+</sup>]i levels regulate numerous processes due to the versatility of the Ca<sup>2+</sup> signaling in terms of speed, amplitude and spatia-temporal patterning. Depletion of …
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Intestinal CD4+T Cell Responses to Food
… Oral tolerance requires CD4<sup>+</sup> T cells including specifically regulatory T cells (Tregs), however the role of intestinal CD4<sup>+</sup> T cells and the T cell repertoire in a physiological response to food protein remains largely unexplored. To characterize intestinal T cell …
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