Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Systems genetics"”.
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Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice
… reported here showed the heuristic value of systems genetics and systems biology approach in the complexity of neurotoxicology and provides clarification of pathways that may underlay sPD pathogenesis.</p> <p>Abstract (Spanish) El paraquat (PQ) es un herbicida que se utiliza en muchos países, …
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Simulation and identification of gene regulatory networks
… (i) the simulation of realistic perturbative and systems genetics experiments in gene networks, and (ii) the inference of gene networks from simulated and real data measurements. In detail, the following themes will be discussed: (i) SysGenSIM, an open source software to produce gene networks with …
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Multipronged Approach to Study Glaucoma-Associated Phenotypes
… address these challenges. First, we used a novel systems genetics approach to identify and validate genetic modifiers of IOP using the enlarged BXD family of strains in combination with human GWAS glaucoma cohorts. This will pave the way for improved drug development tailored to individual …
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Systems Biology Approach to Identifying Host Interactive Pathways Modulating the Severity of Streptococcal Sepsis
… sepsis.</p> <p>To achieve this goal I applied a systems genetics approach, involving genome wide association studies (GWAS) of GAS sepsis in the Advanced Recombinant Inbred (ARI) panel of BXD mouse strains. We used this panel of ARI-BXD strains as a genetically diverse reference population to …
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Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions
… in conferring risk to various cancers. Using a systems genetics approach of GWAS and TWAS, this study sought to investigate two identified genes, ALDH3B2 and FUT2, in order to better understand their potential contributions to colorectal cancer (CRC) risk. ALDH3B2, of the …
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Genetic Effects Mediated Through Epistatic Networks Onto Metabolic Traits
… epigenetic, and environmental information into a systems level framework. In a step towards that goal, quantitative trait mapping studies have attempted to account for environmental factors such as sex and diet, and epigenetic factors such as allelic parent-of-origin effects. Several studies used …
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Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia
Therapy-related acute myeloid leukemia t-AML is a secondary, generally incurable, malignancy attributable to the chemotherapeutic treatment of an initial disease. Although there is a genetic component to susceptibility to therapy-related leukemias in mice, little is understood either about the …