Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Systems Pharmacology"”.
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Towards systems pharmacology models of druggable targets and disease mechanisms
… for the full complexity of biology in humans. Systems pharmacology models are a likely candidate for increasing the efficiency of drug discovery as they seek to comprehensively model the fundamental biology of disease mechanisms in a quantit- ative manner. They are computational models, …
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Systems Pharmacology – Machine Learning Approaches in Profiling Oncology Drug Candidates
While the thesis is framed from the systems thinking perspective, however, the main focus is on the drug discovery and application of machine learning approaches in profiling oncology drug candidates for a select subset of validated targets in the oncogenesis pathways. In this study, we built …
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics: A Quantitative Systems Pharmacology Approach
In this thesis, thermodynamic-based mathematical modelling is combined with experimental in vitro extracellular flux analysis in order to assess drug redox cycling and cellular bioenergetics. It is widely accepted that pharmacological activity of certain classes of drugs (e.g. anticancer, …
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Approximation of Large Stiff Acausal Models
… productivity whilst designing practical systems. In particular, simulating systems with widely separated timescales are prone to computational problem called stiffness. In this thesis, we aim to alleviate these issues by the use of approximate models called surrogates, which match the …
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The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics
… effects on a therapeutic mAb and 3) using a systems pharmacology strategy to model the ontogeny changes in a transport protein (MRP2) and the dynamic effects on its drug substrates. In the preclinical and clinical setting, anti-drug antibodies (ADA) that develop against therapeutic mAbs can …
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Mechanistic modeling of alpha-synuclein aggregation and brain pharmacokinetics for drug development in neurodegeneration
… and methodological aspects of quantitative systems pharmacology (QSP) and physiologically based pharmacokinetic (PBPK) modeling. The first part of the work focuses on the mathematical modeling of alpha-synuclein (aSyn) aggregation dynamics under in vitro conditions—a molecular process …