Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Systemic treatments"”.
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Circulating T-cell subsets in psoriasis- relation to disease activity and response to systemic treatments-
Contains fulltext : 71397.pdf (Publisher’s version ) (Open Access)
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Antagonizing Dorsal Hippocampal Dopamine D1-type Receptors Affects Social Learning and Social Interactions but not Food Intake in Male and Female Mice
… learning, feeding, and social interactions. With systemic treatments, our lab has previously found an involvement of DA D1-type receptors in the social transmission of food preferences (STFP; Choleris et al., 2011), however, the site(s) of action remain unknown. The ventral tegmental area has …
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Reservoir-based devices for the monitoring and treatment of disease
… drug development, and treatment. The systemic route is convenient both for routine monitoring and for drug administration. Local cancer biomarker concentrations, however, are more indicative of the state of solid tumors and their response to therapy. Furthermore, local drug delivery …
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Exploiting p53 mutation in colorectal cancer: clinical positioning of Cdc7 inhibitors
… in combination with current standard of care systemic treatments in CRC were performed and results are presented within the thesis. Importantly, in two models lacking WT TP53, combining LY343921 and chemotherapy indicated that Cdc7i could enhance the in- vitro efficacy of certain standard of …
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Determinants of systemic treatment response in atopic dermatitis
… remain poorly defined. This thesis investigates systemic therapies for AD by integrating real-world registry data, clinical trials, and molecular skin analyses. First, data from the TREATgermany registry were used to compare long-term effectiveness, safety, and drug survival of dupilumab and …
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Unravelling the potential applications of extracellular vesicles for the clinical management of melanoma patients
… increasing. After decades without effective systemic treatments for advanced melanoma, the advent of targeted and immune therapies has substantially improved patient survival. While this is encouraging, further research is needed as the majority of patients treated with targeted therapy …
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Creation and validation of an enhanced in vitro model of the lungs
… of pulmonary drug delivery for local and systemic treatments coupled with the complex lung structure and the numerous factors affecting the pulmonary delivery of drugs has necessitated extensive research on this drug delivery route. The research mostly includes studies on characterization …
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Identification of the Phosphatase NUDT5 as a Target for the Treatment of Triple Negative Breast Cancer
… for affected women. The currently FDA-approved systemic regimens for TNBC patients remain as conventional chemotherapy and PARP inhibitors (only applicable for a subset of BRCA-mutated TNBC patients). Consequently, our focus has been on the exploration of innovative targeted therapies for TNBC. …
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HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanisms
… cancer and potentially delay exposure to systemic treatments that impact quality of life. <br/><i><br/><br/></i>