Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Systemic sclerosis"”.
-
Adipocytes and Innate Immunity In Systemic Sclerosis
<p>Systemic sclerosis (SSc; scleroderma) is a chronic systemic autoimmune and connective tissue disorder characterized by vasculopathy, autoimmune phenomena, and widespread fibrosis. Skin thickening and tightening is the cardinal feature of SSc and is responsible, in part, for the considerable …
-
Marking the immune system in systemic sclerosis
Contains fulltext : 141096.pdf (Publisher’s version ) (Open Access)
-
Deciphering the genetic background of Systemic Sclerosis
Contains fulltext : 99157.pdf (Publisher’s version ) (Open Access)
-
Systemic sclerosis. Novel molecular and epidemiological features of disease.
Systemic sclerosis (SSc) is a systemic rheumatic disease with significant mortality and morbidity. Different estimations of disease prevalence and incidence have been presented from various parts of the world. While lung involvement is a common cause of SSc-related death, a majority of SSc patients …
-
Experience of living with systemic sclerosis - a grounded theory study
Systemic sclerosis (scleroderma) is an autoimmune, rheumatic, and rare chronic and incurable autoimmune disease that damages healthy tissue within the skin, blood vessels, muscles, joints, connective tissues, nerves, vascular system and internal organs (Herndon, 2016). Living with systemic …
-
Accessible and effective non-pharmacological care for persons with systemic sclerosis
Contains fulltext : 289587.pdf (Publisher’s version ) (Open Access)
-
Multi-Functional Optical Coherence Tomography Assesses Skin Involvement in Systemic Sclerosis
Systemic sclerosis (SSc), or scleroderma, is a chronic autoimmune disorder characterized by fibrosis in the skin and internal organs. SSc has a five-year post-diagnosis survival rate of 77.9%, declining to 55.5% after ten years, and a median survival of approximately 11 years, making early …
-
Cardiovascular events and mortality in systemic sclerosis: A study of the effect of Iloprost on these and on disease progression: The SSTEP Study (Systemic Sclerosis Trial of Events and Progression)
Background<br/>Systemic sclerosis (SSc) is an autoimmune disease associated with significant mortality and morbidity. Cardiovascular causes are the single largest contributor to premature death. To date, much of the focus on managing the care of SSc patients has concentrated on traditional risk …
-
FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… with substantial morbidity and mortality rates, systemic sclerosis (SSc) is an autoimmune disorder characterized by vasculopathy, inflammation, progressive perivascular and interstitial fibrosis. SSc pathogenesis is largely unknown, however strong evidences suggest that genetic predisposition may …
-
Improvement of hand and finger function in systemic sclerosis: game-based intervention informed by a 3D assessment of hand mobility
Systemic sclerosis (SSc) is a rare rheumatic autoimmune disease, resulting in increased collagen production, leading to increased thickness and stiffness of the skin and reduced hand function. The hands are a critical contributor to the ability to perform activities of daily living (ADL), which is …
-
La Metabolomica: una nuova era in Cardiologia. Le nostre esperienze originali nei campi dell' insufficienza cardiaca, della cardiopatia ischemica e dell' ipertensione polmonare
… artery disease; c) Pulmonary hypertension in systemic sclerosis. Heart Failure Heart failure (HF) is characterized by a series of maladaptive metabolic changes, which have recently been proposed as a new therapeutic target. A proton nuclear magnetic resonance (1H NMR)-based MBS analysis was …
-
The role of clinical, biological, and socioeconomic factors on the development of resilience in women with autorimmune rheumatic diseases : a cross-sectional study
… in those patients with chronic inflammatory systemic diseases. However, the role of clinical, biological and socioeconomic characteristics in autoimmune rheumatic diseases (ARDs) is still unknown. OBJECTIVE To evaluate the association between resilience and socioeconomic, biological and …
-
Genetic Exploration of Hereditary Immune Diseases
… of autoimmune diseases, rheumatoid arthritis and systemic sclerosis are two of them. My study focuses on these two diseases. Our hypothesis is that mutated genes lead to autoimmune diseases that cause the immune system to attack the human body. The mutated genes cause the gene expression levels to …
-
The characteristics of intersitial lung disease patients attending Groote Schuur Hospital Respiratory clinic
… were predominantly female (81%), diagnosed with systemic sarcoidosis (57%) & connective tissue disease-ILD (CT-ILD) 26%. Hypersensitivity pneumonitis accounted for 5% of follow-up patients, and only 2 IPF patients were in follow-up. CTD-ILD was the most common diagnosis in new patients: 43% and …
-
High-Performance CMOS Front-End ASICs for SiPM Detectors and High-Frequency Ultrasound and Photoacoustic Imaging
… in ophthalmology, intravascular imaging and systemic sclerosis. To break the tradeoff between noise and wideband impedance matching, a wideband low-noise amplifier (LNA) with noise and distortion cancellation is developed. The LNA employs a resistive shunt-feedback structure with feedforward …
-
Expression and regulation of monocyte chemoattractant protein-3 (MCP-3) in fibrosis
Systemic sclerosis is a multisystem connective tissue disease characterised by skin thickening and widespread, but variable, visceral fibrosis. The aetiopathogenesis is likely to involve immunological activation and microvascular dysfunction leading to excessive accumulation of extracellular matrix …
-
Multi and Hyperspectral Imaging of Early Detection of Disease
… nailfold capillaries to aid in the evaluation of systemic scleroderma, and enhancing cancer detection in the gastrointestinal tract during endoscopies. The nailfold capillaries are the smallest blood vessels in the body, and deformations in these capillaries are indicators of systemic scleroderma, …
-
Interstitial lung disease (ILD) in adult patients with autoimmune connective tissue disease (CTD) at Groote Schuur Hospital
… 3 groups of patients: rheumatoid arthritis (RA), systemic sclerosis (SSc) and other autoimmune connective tissue diseases (OCTD) which included idiopathic inflammatory myopathies, mixed connective tissue disease, systemic lupus erythematosus, primary Sjogren's syndrome and overlap syndromes. …
-
Untersuchungen zur Regulation der humanen Xylosyltransferase-I bei Fibrosen
Systemic sclerosis (SSc) is considered a prototypic fibrotic disorder that is characterized by a pathological accumulation of myofibroblasts and extracellular matrix (ECM) components including collagens and proteoglycans (PG). The increase of PG biosynthesis in SSc is closely related to an elevated …
-
Investigating the defects of postnatal global Fli1 deletion in a mouse model
… global postnatal deletion of Fli1 will result in systemic fibrosis, vasculopathy, and inflammation in these mice. The penetrance of a phenotype was highly variable; however, mice that developed a phenotype displayed disorganized vascular networks, fibrosis and proinflammatory cytokines and …
Page 1 of 2