Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Systemic lupus erythematosus ( SLE)"”.
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‘A Nothing Disease?’ An Interpretive Phenomenological exploration of the lived experience of Systemic Lupus Erythematosus (SLE)
… deeper understanding of the lived experience of systemic lupus erythematosus from the perspective of the person who has the condition. A qualitative interpretive phenomenological approach was adopted influenced by Heidegger (1962) with emphasis on existential and interpretive dimensions over …
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Hapten inhibition studies assessing the ability of a thymine derived hapten to bind DNA antibodies in sera from patients with systemic lupus erythematosus (SLE)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Specificity of Anti-Dna Antibodies in Systemic Lupus Erythematosus
… of anti-DNA antibodies in the disease systemic lupus erythematosus (SLE), the specificity of naturally occuring anti-DNA antibody in plasma of human patients with SLE was studied in detail.
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
… immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore a promising target for the development of therapeutics to treat these diseases.
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TREX1 AUTOIMMUNE DISEASE MUTANTS REVEAL DIMERIC STRUCTURE REQUIREMENTS AND THE C-TERMINAL REGION OF TREX1 CONTROLS CELL LOCALIZATION THROUGH UBIQUITINATION
… is the most commonly found TREX1 mutation in systemic lupus erythematosus (SLE) and Aicardi-Goutières syndrome (AGS). The prevalence of this mutation in autoimmune disease and our finding that this mutation affects the activity of the opposing protomer provides direct evidence that TREX1 …
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Identifying a Target Protein and Ligands for Autoimmune Disorders
<p>Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by unprovoked inflammatory responses that lead to tissue degradation. Patients suffering from SLE display an overexpression of master regulatory protein HIF-1 HIF-1is a transcription factor for pro-inflammatory cytokine …
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The Biology of Dendritic Cells in the Context of Autoimmunity
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects at least five million people worldwide. An increased expression of type I interferon (IFN) regulated genes is a hallmark of SLE, but the precise etiology of SLE initiation and flares is poorly understood. Because …
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SAFETY, EFFICACY, AND IMMUNOGENICITY OF SARS-COV-2 MRNA VACCINES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
… and efficacy in autoimmune conditions like systemic lupus erythematosus (SLE), a type 1-interferon-driven disease, remain uncertain, as their mechanism of inducing T-cell-mediated responses and antibody production may risk exacerbating underlying immune dysregulation. This study evaluated …
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Novel protocols to induce tolerance to solid organ transplants
… rejection or in autoimmune diseases such as systemic lupus erythematosus (SLE). In this thesis, we present data pertaining to three different approaches for targeting DC activation including 1) the use of ethyl p
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Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor
… Peichlin, 1971; Sharp, et al., 1972) of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding both the relationships of antibody specificities to disease and the biological roles of the recognized antigens. …
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Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis
… disease (RHD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are autoimmune diseases with drastic effects on quality of life. Diagnostic challenges remain, especially given the prevalence of these diseases among people of low socioeconomic status. The purpose of this review …
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Proline-rich acidic protein 1 in Life and Death
… cells, derangement of which may lead to systemic lupus erythematosus (SLE). In conclusion, PRAP1 is multifunctional protein with antimicrobial and cell fate modulation properties, which presents a novel target in the treatment of CRC and SLE.
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Development and validation of the BILAG-2004 Index for the assessment of disease activity in systemic lupus erythematosus
… assessment of disease activity in patients with [systemic lupus erythematosus] SLE had involved several validation studies. The reliability of this index was shown in 2 exercises, as assessed by level of agreement, kappa statistic, ICC and disagreement between physicians. This study also …
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Spirituality And Systemic Lupus Erythematosus
… in a sample of individuals diagnosed with Systemic Lupus Erythematosus (SLE). Furthermore, relational spirituality has yet to be studied in a chronically ill population. Meeting these gaps in the literature, this study compared the explicit domains and latent constructs measured by a …
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The Relationship of Perceived Social Support, Health Status, and Quality of Life in Female Systemic Lupus Erythematosus Patients
… and quality of life in a sample of female systemic lupus erythematosus (SLE) patients. A strong positive correlation was found between perceived social support and quality of life. Negative correlations were found between perceived health status and perceived social support, and perceived …
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Immune memory and activation markers in systemic lupus erythematosus
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the loss of tolerance to self-antigens, immune complex deposition, tissue inflammation and destruction. SLE manifestations, prevalence and severity vary among different populations and ethnicities. Even …
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High prevalence of metabolic syndrome in patients with SLE in the Western Cape
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at increased risk of the metabolic syndrome (MetS) and its complications. In the absence of published studies from sub-Saharan Africa, we investigated the prevalence and associations of the MetS amongst recent-onset SLE patients. …
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The Nonenzymatic Modification of Proteins by Steroids and DNA by Reducing Sugars; In Vitro and In Vivo Studies
… in elevated amounts in the autoimmune disease Systemic Lupus Erythematosus (SLE). Protein modification by this steroid might induce immune dysfunction by either hapten formation or by covalently modifying immunoregulatory proteins.</p>
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Insights into the Iimmune Mechanisms Leading to Lupus-like Autoimmunity in New Zealand Black Mice
Systemic lupus erythematosus (SLE) is a chronic, multi-organ autoimmune disease characterized by the production of antibodies against self nuclear antigens. Genetics play a dominant role in disease pathogenesis and functional examination of spontaneously-arising lupus-prone animal models has …
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Using urinary MCP-1 and TWEAK to assess disease activity in a cohort of South African patients with lupus nephritis
Background: Renal involvement is common in systemic lupus erythematosus (SLE) and can lead to chronic kidney disease (CKD). Diagnosis of lupus nephritis (LN) is dependent on renal biopsy. Due to its invasiveness, repeat renal biopsy for monitoring disease activity is not recommended, thus creating …
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