Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Systemic dissemination"”.
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Investigation of mechanisms underpinning host-microbial interactions in the gastrointestinal tract
… a library of bacteria that disseminate to systemic tissues in mice. This approach could now be applied in research studies targeted at studying systemic dissemination using small animal models. In the third study (Chapter IV) we use the developed method to show that systemic dissemination …
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Identification of the role of the sal locus in streptococcus pyogenes virulence during host-pathogen interactions
… the blood stream, which consequently inhibited systemic dissemination to the spleen. The attenuation of the ΔsalKR mutant in the blood stream was due to its sensitivity to intracellular and extracellular killing by neutrophils. This was most likely a consequence of the high susceptibility of the …
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The pathogenesis of murine retroviral-induced noninflammatory spongiform polioencephalomyelopathy: Neuronal degeneration is indirectly mediated by resident microglial cells
… platelets, and cell free viremia contributed to systemic dissemination of virus to the CNS. Resident microglia served as the major reservoir and amplifier of virus infection in the CNS of ts1 MoMuLV-infected mice; a similar but much less significant role was played by microglia in wt …
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Natural Killer Cell Recruitment and Activation Following Orthopoxviral Infection
… cells for resistance to orthopoxviral infection. Systemic depletion of NK cells prior to CPXV infection resulted in increased viral replication and systemic dissemination. Recruitment of NK cells to the draining LN was pertussis toxin sensitive indicating chemokine receptor dependence. Candidate …
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Self-assembly of human defensin 6 and its role in innate immunity and siderophore-based strategies to target Gram-Negative bacteria
… exhibit reduced intestinal colonization, reduced systemic dissemination of S. Typhimurium, and increased resistance against the challenge of this pathogen.
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The Molecular Characterization of Phosphorylcholine (ChoP) on Histophilus somni Lipooligosaccharide: Contribution of ChoP to Bacterial Virulence and Pathogenesis
… in the process of colonization and subsequent systemic invasion of host tissues, which may occur through binding of ChoP to PAF-R. Bacteria that did not express ChoP were more prevalent in systemic sites, indicating that ChoP expression may be disadvantageous for the organism during systemic …
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Epidemiology of Chlamydiaceae in livestock and emerging Chlamydia psittaci infections in chickens
… observed in all infected animals, indicative for systemic dissemination as proven by immunofluorescence staining of frozen tissue sections. Histopathological lesions were present in all infected chickens. However, differences in pathology were observed as genotype D was more virulent than genotype …
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Exploring the Polyclonal Antibody Responses Induced by Klebsiella pneumoniae Derived Outer-Membrane Vesicles
… model; however, immunising with OMVs did prevent systemic dissemination of bacterial cells. This thesis demonstrates the importance of retaining the genomic diversity of K. pneumoniae within experimental design as well as providing novel insights into polyclonal antibody responses against K. …