Global ETD Search
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Showing 1 to 6 of 6 for “"Systemic autoimmunity"”.
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Mechanistic Insights on The Immunomodulatory Functions of Diverse Environmental Factors on Systemic Autoimmunity
… threats while avoiding both immunodeficiency and autoimmunity. The skewness towards inflammatory responses causing excessive collateral damage could lead to diverse autoimmune conditions. These conditions could be organ-specific or result from systemic immune dysregulations called systemic …
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Narrowing of the SLES1 Internal Reveals Complex Epistatic Interactions in the Suppression of Autoimmunity
… is a potent susceptibility locus for spontaneous systemic autoimmunity derived from the NZM2410 mouse strain. The NZW-derived suppressive modifier locus, Sles1, specifically prevents the spontaneous loss in tolerance mediated by the B6.Sle1 congenic. Sles1 had previously been fine-mapped to a …
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The role of gut microbiota in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with no known cure. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. Gut microbiota as an environmental factor and the immune …
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Tim-3 and Cell Death in Murine Mercury Induced Autoimmunity
… diseases. The rodent model of Hg-induced autoimmunity is useful for the analysis of systemic autoimmunity that is both environmentally and genetically modulated. In susceptible mice, Hg treatment induces both polyclonal activation of B cells, as well as the production of highly specific …
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Apoptotic Cells, Anti-Phospholipid Antibodies, and Anti-Chromatin Antibodies in Autoimmunity
… such as antiphospholipid syndrome (APS) and systemic lupus erythematosus. In addition to their binding to negatively charged phospholipids, APAs often cross-react with other molecules. Their potential biological effects are not fully understood. Apoptotic cells are a potential source of …
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Haplotype-Specific Effects of the Slam/Cd2 Family on the Immune Response
… to nuclear antigens in the NZM2410 model of systemic lupus erythematosus (SLE). Congenic B6 mice carrying the Sle1b locus produce anti-nuclear autoantibodies (ANAs) but do not develop lupus nephritis as seen in the parental NZM2410 strain. Fine mapping of the Sle1b locus placed it within a …