Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Systemic Therapy"”.
-
Ultrasound-based functionalized biopsy markers for lesion tracking through neoadjuvant systemic therapy
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
-
Treatment response using CT-based rigidity analysis in an animal model of lytic musculoskeletal lesions subjected to systemic therapy
Cancer is a global epidemic; over 1.5 million new cancer diagnoses and greater than 600,000 deaths due to cancer are estimated to occur in the United States within the year 2015 alone. Approximately two-thirds of patients with bone metastases will experience pain, pathological fractures, spinal …
-
Course of clinical response during primary systemic therapy with a dose-dense 4 cycles regime of adriamycin and docetaxel in patients with operable cancer of the breast
Background: <br>In contrast to adjuvant chemotherapy (AST), primary systemic therapy (PST) allows the observation of clinical response under treatment, serving as an in-vivo chemosensitivity test. One possibility to assess tumor response is the consideration and analysis of clinical parameters such …
-
The perioperative setting as a platform for breast cancer biomarker development
… new cases globally in 2022 (1). ‘Neoadjuvant’ systemic therapy prior to surgery is the standard of care for stage II-III human epidermal growth factor receptor-2 (HER2) positive breast cancer. The identification of predictive biomarkers of response to systemic therapy is of great research …
-
IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS
… insights into the mechanism of action of a novel systemic therapy. Therefore, this dissertation will show that HCC - specific AM RF EMF’s antiproliferative effects are mediated by Ca 2+ influx through Ca v 3.2 T - type voltage - gated calcium channel (CACNA1H). This finding establish es a key …
-
Cost-Effectiveness Analysis of Tisagenlecleucel, Blinatumomab, and Clofarabine for Treatment of B-cell Precursor Acute Lymphoblastic Leukemia
… or relapsed after receiving two or more lines of systemic therapy have the option of taking tisagenlecleucel. Due to the high cost of this treatment, a cost-effectiveness analysis was performed to assess the treatments for tisagenlecleucel, clofarabine combination, and blinatumomab. Objectives</p> …
-
Pathologic Markers of Prognosis In Ampullary Carcinoma
… of localized disease. The benefit of adjuvant therapy, however, remains unknown in these patients partly because of difficulty in stratifying which patients are at high risk for recurrence. To better identify those patients who may benefit from adjuvant therapy, I conducted a retrospective …
-
Comprehensive discourse analysis of symbolic externalization
… intervention in successful Experiential Systemic Therapy (ExST) for marital treatment of alcohol dependence through a single case study design. A comprehensive discourse analysis method was used to study the therapeutic conversation within a 15 minute therapy episode in which therapist …
-
Impact of Cyclin-Dependent Kinase 4 and 6 Inhibitors on Chemotherapy Utilization and Overall Survival in Women with HR+/HER2– Metastatic Breast Cancer in the United States
Purpose: Delaying chemotherapy remains a vital goal in therapeutic management of HR+/HER2– metastatic breast cancer (MBC). However, recent reports continue to highlight substantially high chemotherapy utilization in earlier therapy lines. In this study, we explored the impact of cyclin-dependent …
-
Polymeric nanocarriers for the regional and systemic delivery of therapeutics to and through the lungs
… underutilized to target ailments not only of systemic relevance but also several other grave conditions including lung cancer and tuberculosis. Polymeric nanocarriers (PNCs) have several advantages over other drug delivery vehicles including sustained release of moieties, ease of cellular …
-
“IN OUR OWN WORDS”: THE PHENOMENOLOGICAL EXPLORATION INTO THE AFRICAN AMERICAN EXPERIENCE OF RELATIONAL THERAPY WITH WHITE THERAPISTS
… cultural context is a critical component of systemic therapy. Marriage and family therapy literature underscores this importance with a wealth of information on working with various diverse family systems. The literature has not adequately reflected the voices of the African American client. …
-
The language of family therapy : what we say we do and what we actually do in therapy
Systemic family therapy, as a variant of the "talking cure", has developed its conceptual base during the second half of the twentieth century. Its founding fathers and mothers made a conceptual break with psychoanalysis, and this theoretical distinction has until recently been well established. …
-
Θεραπεία μονής συνεδρίας στη συστημική ψυχοθεραπεία: συστηματική ανασκόπηση ως προς την αποτελεσματικότητα
… Η Θεραπεία Μονής Συνεδρίας-ΘΜΣ (Single-Session Therapy, SST) αποτελεί τον συντομότερο τύπο βραχείας ψυχοθεραπείας και εφαρμόζεται διεθνώς για πάνω από τριάντα χρόνια. Σκοπός της παρούσας μελέτης είναι η παρουσίαση της ΘΜΣ στην ελληνική επιστημονική κοινότητα και η διερεύνηση της …
-
The Martial Arts Project: Exploring the Use of the Martial Arts as an Intervention for Young Offenders with Substance Influenced Violent Offences
… therapies, such as cognitive behavioral therapy and multi-systemic therapy, have been used to address substance use and violent behaviors in young offenders and have shown success. This study explores the question of the effectiveness of alternative methods of intervention, such as the …
-
The effectiveness of a community-based intensive intervention for young people with complex psychological and forensic needs
… intervention is based on the principles of Multi-Systemic Therapy (MST), a renowned intensive, community-based intervention for aggressive, violent and antisocial young people, which is explored in the literature review (Chapter 1). The available evidence-base on MST demonstrates that the …
-
Temozolomide and Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor
… gemcitabine based, or paclitaxel chemotherapy as first- or second-line therapy, the overall RECIST response rate was 0%. Most patients achieved a brief duration of disease stabilization on chemotherapy, with median progression-free survival (PFS) period of 4.6 months. For the 14 …
-
Synovial sarcoma : translating gene expression into patient care
… of whom are young adults. The addition of chemotherapy to surgical resection (the mainstay of treatment) does not appear to improve overall survival. Thus, there is a strong need for development of a clinically effective systemic therapy to improve patient outcome. I describe preclinical studies …
-
Development of Topical Ophthalmic In Situ Gel-Forming Estradiol Delivery System Intended for the Prevention of Age-Related Cataracts
… the reduced risk in women on hormone replacement therapy, and studies in animal models suggest that estrogen may protect lens transparency. To use estrogen for cataract prevention, we hypothesized that an ophthalmic estradiol in situ gel-forming formulation would be more effective for inducing …
-
Quantifying, Understanding and Predicting Differences Between Planned and Delivered Dose to Organs at Risk in Head & Neck Cancer Patients Undergoing Radical Radiotherapy to Promote Intelligently Targeted Adaptive Radiotherapy
Introduction: Radical radiotherapy (RT) is an effective but toxic treatment for head and neck cancer (HNC). Contemporary radiotherapy techniques sculpt dose to target disease and avoid organs at risk (OARs), but anatomical change during treatment mean that the radiation dose delivered to the …
Page 1 of 2