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Showing 1 to 9 of 9 for “"System xc-"”.
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Modulating System xc- Activity As A Treatment For Epilepsy
… otherwise have no effective treatment options. System xc- (SXC), a cystine/glutamate antiporter expressed in astrocytes, is one such target that has been shown to play a critical role in establishing ambient extracellular glutamate levels in both health and disease. SXC has been shown to play a …
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… of neurological disorders of the Central Nervous System (CNS). Glutamate, a major excitatory amino acid in the CNS, works through four different classes of receptors; three that are heterogeneous, ionotropic excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). …
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… of neurological disorders of the Central Nervous System (CNS). Glutamate, a major excitatory amino acid in the CNS, works through four different classes of receptors; three that are heterogeneous, ionotropic excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). …
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GLIOBASTOMA MULTIFORME UTILIZES SYSTEM Xc¯ FOR SURVIVAL UNDER OXIDATIVE STRESS AND PROMOTES CHEMORESISTANCE
… ROS neutralization capabilities are sustained by system Xc<sup>–</sup>, a sodium-independent, electro neutral transporter that is found in the plasma membrane of GBM cells. System Xc<sup>–</sup> is composed of a regulatory heavy subunit (4F2hc) linked to a 12 transmembrane domain catalytic light …
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Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
<p>System xc- (Sxc-) is a cellular antiporter that links the import of L-cystine with the export of L-glutamate. In the central nervous system (CNS), this export contributes to the ambient glutamate levels found in the synaptic cleft. To wit, a 50% reduction in extracellular glutamate has been …
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
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Modulation of System x<sub>c</sub>- Mediated Glutamate Release in Glioblastoma Multiforme via the Extracellular Matrix: The Agony and the Xctasy
… is upregulation of the transmembrane protein system xc- (SXC) found on GBM cells. Approximately 50% of GBM patients have tumors with upregulated levels of SXC, and these patients experience faster disease progression than patients with tumors expressing moderate levels of SXC. SXC is a …
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CHCHD2 and the tumor microenvironment in glioblastoma
… independent of GSH synthesis, cystine import via xCT, or GPx-1, GPx-2, or GPx-4 levels. The cytosolic GSH pool was not perturbed by CHCHD2 KO. Furthermore, CHCHD2 KO abrogated the increased proliferation and invasion of U87vIII cells in hypoxia (1% O2) compared to standard normoxic culture …