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Showing 1 to 20 of 38 for “"Synthon"”.
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Carbanionisch vermittelte „Methylen“-Insertionen mit N,N-Dimethylformamid als C1-Synthon
… „Methylen“-Insertionen mit DMF als C1-Synthon basieren. So entstehen bei der Umsetzung von Phenylessigsäureamid unter Rückfluß aus jeweils zwei Edukt- und einem DMF-Molekül neben 3,5-Diphenylpyridin-2,6-diol und 3,5-Diphenylpyridin-2-ol (I) die methylenverbrückten Dimere racem- und …
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Synthesis and Characterization of Metal-Organic Frameworks Organized by the Strong π...π Stacking 1,8-Naphthalimide Synthon
… noncovalent interactions of the naphthalimide synthon, the larger size of cadmium(II) leads to a highly distorted</p> <p>9 structure about the metal. The copper(II) structure is also distorted, as expected for a d</p> <p>complex. New enantionpure trifunctional carboxylate ligands have also been …
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Synthesis and Reactivity of Phosphorus-Containing Heterocycles and Tetrahedranes
… reaction. MesN₂PA (Mes = mesityl), a synthon of mesitylphosphaazide (MesN₂P) and anthracene, was synthesized by treating [Ph3BPA][Na(OEt₂)₂] with [MesN₂]OTf (OTf = CF₃SO₃ −). MesN₂PA reacts with alkynes and phosphaalkynes to form the corresponding [3+2] phosphaazide-(phospha)alkyne …
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Chemistry of oxa- and aza-bicyclic(4.1.0)heptenes, total synthesis of (+)-pancratistatin
… indicate that 6 and 7 could serve as useful new synthons for C-disaccharides and Amaryllidaceae alkaloid syntheses. The utility of synthon 7b has been demonstrated by a concise enantiocontrolled synthesis of (+)-pancratistatin (9). The key step involved the S<sub>N</sub>2 opening of 7b with the …
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Thiopyran route to polypropionates : simultaneous-two directional and enantiotopic group selective aldol reactions
… reaction affording a non-racemic hexapropionate synthon. This chemistry is discussed in section 2.5. Section 2.6 discuses the assignment of the relative and absolute configurations of the various aldol adducts via NMR and X-ray. To demonstrate the synthetic usefulness of this research, the …
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Optimalios sarpaginų šeimos alkaloidų sintezės paieška /
… the potential of the 9-azabicyclo[3.3.1]nonane synthons for de novo construction of the indole moiety of cycloocta[b]indole core is considerably less explored. In this work, a generalized synthetic access to Sarpagine alkaloids through a new synthon based on 9-azabicyclo[3.3.1]nonane core is …
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Novel acyclic nucleotide phosphonates against RNA viruses
… protected phosphonomethoxyethyl (PME) synthon and included an arylethynyltriazole derivative which was produced via a Sonogashira palladium catalysed cross-coupling reaction. A selection of these compounds was then deprotected to their corresponding phosphonic acids via a …
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The Design and Synthesis of Novel Chiral Z-Nitrones with Applications Towards the Syntheses of Enantiomerically Pure 4-Hydroxy Amino Acids
… was determined to be the best synthon in cycloadditions that favored a Z-nitrone oriented transition state. Solvent studies were performed for cycloaddition reactions and it was determined that polar solvents lead to "Z-derived" isoxazolidines whereas non-polar solvents …
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
… of Ser was reacted directly with an aminyl synthon. The reaction was catalyzed by HgO and HgCl2 to form an α-hydroxyamide. Hydrolysis and coupling were combined in one step in 80% yield. Two diastereomers of a phospho-Ser-Pro α-ketoamide analogue were synthesized. The resulting IC50 values …
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cis-Arenediols as versatile chiral synthons in the synthesis of prostaglandins, cyclitols, carbohydrates, and alkaloids
… are enantiomerically pure and can be used as synthons for the preparation of a variety of interesting compounds because of their stereochemistry and the special array of functional groups. See: Figure 1 cis -Toluenedio] (2) served as a chiral intermediate in an efficient synthesis of enone …
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Impact of mixed solvent on co-crystal solubility, ternary diagrams and crystallisation scale-up. Crystallisations of Isonicotinamide ¿Benzoic Acid Co-crystals from Ethanol ¿Water Co-solvent System.
… the desired former and co-former. Therefore the synthon approach was utilised to design co-crystals with the specific properties, this involves the understanding of the intermolecular interactions between these synthons. These interaction forces can be directed to control the crystal packing in …
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Impact of mixed solvent on co-crystal solubility, ternary diagrams and crystallisation scale-up. Crystallisations of Isonicotinamide ¿Benzoic Acid Co-crystals from Ethanol ¿Water Co-solvent System.
… the desired former and co-former. Therefore the synthon approach was utilised to design co-crystals with the specific properties, this involves the understanding of the intermolecular interactions between these synthons. These interaction forces can be directed to control the crystal packing in …
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Design and synthesis of novel sulfur-containing antiviral analogues
… the base labile 2-cyanoethyl group as a synthon. Chapters Four and Five describe our various, ultimately unsuccessful attempts at preparing our target molecule and similar compounds employing the chemistry which we developed in the course of our model study. A series of complementary …
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The acid-catalyzed self-condensation reaction of b-diketones in the presence of 2,2,2-trifluorodiazoethane
… One of these groups could be an important synthon for the preparation of larger polycyclic aromatic compounds. Several cyclized products have also been obtained from the reaction of 2, 4-pentanedione with TFD. Two potential mechanisms have been suggested to describe this cyclization …
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An exploration of supramolecular tape-like assemblies formed by pyridine dicarboxylates
… towards the use of the 2,6-pyridinedicarboxylate synthon in the synthesis of functional materials. The solid-state behaviour of a number of other pyridine derivatives prepared during the course of the present study is described in Chapter 7.<br/>
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Lewis Base Promoted Annulations of Allenoates with 1,4-Naphthoquinones
… allenic ester to act as a two or three carbon synthon. The allenoate can then react with varying electron deficient olefins generating more complex molecules with high atom economy and few byproducts.</p> <p>The development of complex small molecules using easy to obtain starting materials such …
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Preparation and Evaluation of Molecular Imaging Probes Targeting the Urokinase Plasminogen Activator System
… functionalized biomolecules. A new tetrazine synthon was developed that can be readily labeled with both 99mTc and 18F where the products were produced in 75 and 31 % radiochemical yields. Stability studies showed the compounds are suitable for use in vivo. Biodistribution studies were carried …
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Development of novel polymeric architectures for applications in drug delivery and studies towards the synthesis of perfect polymers by iterative exponential growth "Plus" (IEG+)
… both as a protecting group and as a masked synthon for alcohols, which allowed for side-chain functionalization of the IEG+ scaffold. Combing R- and Smonomers afforded complete stereochemical control of the IEG backbone. Oligomers of unimolecular molar mass and precise chemical structure …
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Novel nitrogen containing polymers via Reissert chemistry
… the reaction of a masked carbonyl carbanion synthon with activated aromatic fluorides. Hitherto unknown poly(aryl ketone sulfone)s were synthesized when this chemistry was extended with the use of bis(α-aryl aminonitrile)s. A novel quinodimethane was synthesized in quantitative yield by an …
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