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Showing 1 to 20 of 21 for “"Synthetic scheme"”.
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Dinitrogen fixation chemistry of a molybdenum trisanilide system
… ultrafast transient absorbance spectroscopy. A synthetic scheme for nitrogen fixation in the form of organic nitriles is initiated from the product of dinitrogen cleavage, N=Mo(N[t-Bu]Ar)3. This synthetic scheme is a closed cycle that returns the molybdenum nitride starting material at the …
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Syntheses of Azido- and Diazido- 10-Methylacridinium Salts.
… corresponding nitro- and diaminoacridines. The synthetic scheme involved reduction of the nitro group to an amino function, acetylation of the primary amino group, methylation of the ring nitrogen with subsequent removal of the protecting group and diazotization of the primary amine followed by …
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Synthesis and characterization of conducting polymers with new architectural motifs
… monomers did occur. In chapter three, a synthetic scheme was developed to generate 2,2'-biphenyl monomers with long alkyl chains from which soluble polymers could be generated.
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In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles
… therapeutic delivery applications in cancer. The synthetic scheme includes the enzymatic polymerization of multifunctional linker molecules (dimethyl 5-hydroxyisopthalate) with poly(ethylene glycol). This chemoenzymatic synthesis is much faster and more convenient than an entirely chemical …
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Synthesis and Application of Boronic Acid Derivatives
Boronic acids are attractive synthetic intermediates and have been shown to be effective as inhibitors of various enzymes. In this project, the overarching goal is the selective inhibition of a protease present in the mitochondria known as human ClpXP. To study the potential selective inhibition of …
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Ruthenium-Platinum Polypyridyl Complexes: Synthesis and Characterization
… to the series of complexes within the general synthetic scheme. This illustrates the applicability of this scheme to the development of new series of complexes. The lowest-energy absorption for the three complexes is assigned to a Ru(dπ) → BL(π*) charge transfer transition. This transition …
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Tandem, Oxidative Cyclizations By Anodic Electrochemistry And The Use Of Solar Power As An Alternate Energy Source
… excess waste and decrease the efficiency of a synthetic scheme. In these cases, it would be nice to do the cyclization in an oxidative fashion. Oxidative cyclizations have been performed, but are currently limited in nature and scope. One way to address this issue is with the use of organic …
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Synthesis and characterization of phosphorous containing macromolecular polyether compounds
… done using HPLC, NMR and ESI-MS techniques. The synthetic scheme used was demonstrated to be plausible and could be used to obtain ionizable phoshobipodands. Extraction using solid phase anion exchange columns proved to be a good clean up procedure for obtaining pure bipodand. This bipodand could …
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Design, Synthesis and Study of Novel Multivalent Ligands - Toward New Markers of Cancer Cells
… efficiently with good yields. The established synthetic scheme is empowered by its modularity, necessary to investigate different essential factors. Trimers composed of micromolar affinity MSH(4) targeting the MC1-R, overexpressed in melanoma, were investigated on a model cell line and resulted …
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Synthesis of a triglyceride containing a lactonizable hydroxy fatty acid and investigations into the behavior of this triglyceride and related lactones with application to the analysis of beef tallow
… 5-ketododecanoic acid as an intermediate in the synthetic scheme. The initial step in the developed methodology for analysis of lactones and hydroxy fatty acids was silica gel column chromatography to concentrate the polar fraction of beef tallow followed by a digitonin column which enabled the …
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Synthetic Design of Optical Emitters
… sophisticated applications demand the continuous synthetical improvement, as well as the development of conceptually new, classes of emitters. In the first part of this thesis, I detail a new approach to the precursor chemistry of indium arsenide (InAs) QDs based on the redox chemistry of In. The …
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High Performance Materials Containing Nitrile Groups
… while maintaining flame resistance. A four step synthetic scheme has been developed to prepare 4,4′-Bis(3,4-dicyanophenoxy)biphenyl(biphenoxyphthalonitrile). A 700 g mol-1 novolac oligomer was cured with relatively low concentrations of this reagent (~20 wt %) into high Tg (~190 °C) networks. The …
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Design and applications of 4-yl-(methyl)coumarins and their derivatives
… available starting materials. A divergent synthetic scheme was developed that allows access to a variety of coumarin photofuses, via similar synthetic pathways, that enable multiple surface modifications. After establishing this synthetic pathway, various coumarin photofuses were prepared …
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Part A, Synthesis of new 2-substituted-3-aryl-4(3H)-quinazolinones as potential CNS agents: part B, Reactions of β-diketones with benzophenone in the presence of potassium hydride
… various other esters were employed in this synthetic scheme to prepare a representative group of derivatives of this pharmacologically active parent molecule. Likewise, other 2-methyl-3-aryl-4(3H)-quinazolinones were similarly acylated and a preliminary structure-activity correlation with …
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Metabolic pathways of Campylobacter fetus
… is actively operating and presumably served as a synthetic scheme for the formation of hexose phosphate in the organism. The oxidative portion of both the hexose monophosphate pathway and phosphoketolase pathway, and the entire Entner-Dudoroff pathway were not found in 482. But the non-oxidative …
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Implementation of Solution and Solid Sate Nuclear Magnetic Resonance (NMR) Spectroscopic Techniques for Quantitative and Qualitative Analysis of Molecular Species
… of phenylboronic acid was synthesized. The synthetic scheme and the spectroscopic results are presented and discussed in detail. The objective of part II (applications of solid-state NMR spectroscopy) is to apply SSNMR spectroscopy experiments in two projects to gain significant information …
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Synthesis of Novel Amino Acids and Peptidomimetics as Tools for Drug Discovery
… on the surface of specific inflamed tissues. The synthetic methodology for the preparation of the three series of biotin-R8ERY* peptidomimetics is outlined in Scheme 1. Scheme 1. Synthetic scheme summarising the preparation of the three series of biotin-R8ERY* peptidomimetics. The second part of …
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Development of N-domain selective Angiotensin-I Converting Enzyme (ACE) inhibitors using Computer Aided Drug Discovery (CADD)
… were docked against the two domains of ACE and a synthetic scheme was developed to synthesise compounds from this library. Using this scheme, one Enalaprilat analogue, SF07 was synthesised as a mixture of diastereomers. SF07 exhibited low micromolar N-domain inhibition with no C-domain inhibition …
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Synthesis and Characterization of Bexarotene Derivatives with Potential Biological Activity // Получаване и охарактеризиране на бексаротенови производни с потенциална биологична активност
… of the newly synthesized derivatives of the synthetic retinoid bexarotene. The continued and intensive study of the role of retinoids in the complex of differentiation, cell proliferation, and cellular growth processes determines the major potential for the using of retinoids (natural and …
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
… markers. This study offers a convenient synthetic route using a novel intermediate 1α,3β-diacetoxypregn-5-en-20-one, and provides molecular basis of design for drug development of 1,20S(OH)2D3 and its analogs. Overall, we have synthesized and biologically evaluated four series of …
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