Global ETD Search
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Showing 1 to 7 of 7 for “"Synthetic receptors"”.
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Molecular tweezers: Synthetic receptors for the DNA base adenine
The design and syntheses of a series of molecular tweezers containing functional groups in the bay area of the spacers are discussed. Molecular tweezers 98, 99, 120, and 128 were designed to complex the DNA base adenine through a combination of hydrogen bonding and $\pi$-stacking interactions. They …
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Molecular recognition with synthetic receptors ; Development of new chiral auxillaries
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1991.
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Part I. Molecular Tweezers: Synthetic Receptors for Nucleotide Bases. Part II. Molecular Self-Assembly: Design of a Helical Aggregate
In Part I, the design, syntheses, and complexation studies of molecular tweezers containing active site carboxylic acids are discussed. The strength, nature, stoichiometry, and geometry of the complex between molecular tweezer 28 and 9-propyladenine was studied. The cooperativity of hydrogen …
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Synthesis towards synthetic adenosine receptor
… of the body. However its selective detection by synthetic receptors is not possible till date. Efforts have been made here to design molecular tweezer for adenosine. Multistep synthesis was done to synthesize two clamps, namely the [pi]-[pi] stacking clamp and the hydrogen bonding clamp for the …
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Allosteric Interactions in Coordination Cages
Biomolecular receptors can catalyse reactions, alter their geometry, and inhibit their activity in response to molecules binding around their periphery. Synthetic receptors that can mimic this allosteric binding behaviour extend the potential applications of host-guest chemistry to programmable …
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Novel immunotherapy for paediatric cancers
Chimeric antigen receptors (CAR) are synthetic receptors that redirect T lymphocytes to specific tumour antigens. CART cells targeting CD19 (CAR19) have demonstrated remarkable efficacy against B cell malignancies in clinic. Currently used methods of CAR gene transfer to T cells based on viral …
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Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery
… work presents novel methods for immobilizing synthetic receptors on the red blood cell surface. These receptors are used in proof-of-concept experiments to investigate requirements for efficient invasion via a well-characterized P. falciparum invasion pathway, suggesting this method can be …