Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Synthetic hydrogel"”.
-
Synthetic Hydrogel Delivery of Growth Factors and Demineralized Bone Matrix for Bone Augmentation
… objective of this thesis was to investigate synthetic hydrogel delivery of growth factors and demineralized bone matrix (DBM) for bone augmentation. Our motivation rests on observed weaknesses of current clinical approaches to bone augmentation, which synthetic hydrogels hope to overcome …
-
INDUCIBLE CELL EXPRESSION OF MMP1A FOR TUNABLE DEGRADATION OF BIOMIMETIC SCAFFOLDS
… surrounding cells. Recent advances have explored synthetic hydrogel scaffolds aimed at mimicking the ECM to create prevascularized tissues. These hydrogels include cell adhesion peptides, enzyme degradable sequences, and growth factors for endothelial cell homing, matrix remodeling, and …
-
Surface mechanics of polyacrylamide hydrogels following wear
In this work, the changes in elasticity of synthetic hydrogel surfaces following deliberate abrasive surface wear are measured. These polyacrylamide hydrogels – cross-linked polymers consisting of 92% water by mass – undergo surface wear, and their surface elastic properties before and after wear …
-
Development of an Injectable Hydrogel Platform to Capture and Eradicate Glioblastoma Cells with Chemical and Physical Stimuli
… of the primary GBM tumor mass, an injectable hydrogel can be dispensed into the resection cavity for crosslinking in situ. A combination of chemical and physical cues can then induce the migration of the residual GBM/GSCs into the injectable hydrogel to localize and concentrate the malignant …
-
Hindered transport in composite hydrogels
… by measuring macromolecular permeability through synthetic, two-fiber, agarose-dextran hydrogels at very small or very high Pe, respectively. By comparing diffusion and convection in the synthetic hydrogel with corresponding measurements in isolated rat GBM, further insight regarding the structure …
-
Orienting structure to serve medical functions
… A 3D printed physical phantom and a hydrogel coated orthopedic implant were developed. The purpose of physical phantom work was to characterize and improve the ability of fused filament fabrication to create anthropomorphic physical phantoms for CT research. Specifically, we sought to …
-
Development of thermally-crosslinked hydrogels as injectable cell carriers for orthopaedic tissue engineering
Synthetic hydrogel materials based on oligo(poly(ethylene glycol) fumarate) (OPF) were developed and characterized as injectable cell carriers for orthopaedic tissue engineering. Through alteration of the poly(ethylene glycol) molecular weight used in the synthesis of the OPF macromer, swelling and …
-
Chemomechanics of self-oscillating gels
… and chemical signals throughout the body. Few synthetic materials have been engineered to produce communicative chemical signals in response to mechanical input, though such synthetic material analogues could enable devices that mimic biological tissues and pressure sensitive processes whereby …
-
Microfluidic-based 3D cell culture for studies of biophysical and biochemical regulation of endothelial function
… culture of cells on/in biologically-derived or synthetic hydrogel scaffolds and allows for controlled flow rates, pressure and concentration gradients while directly visualizing cellular response. In addition to the realtime and post-fixation imaging using optical microscopy, methods were …
-
A Human Pluripotent Stem Cell-Derived Model for the Investigation of Thermogenic Adipocyte Development and Function
… efficiency and maturity. I test three synthetic 3D culture systems and identify the PuraMatrix hydrogel as suitable for hPSC-derived BA culture. This hydrogel was able to increase differentiation efficiency of hPSC-derived BAs. Finally, having shown that a synthetic hydrogel scaffold is …
-
A Novel Biomaterial Enables Chemotactic Study of Motile Central Nervous System-derived Tumor Cells
… of Laminin-Collagen 1 and a cellulose derived synthetic hydrogel, CMC. The average changes in cell morphology, over time in 2D and 3D are quantified using the NIH software, ImageJ, to reveal that CMC allows for a cell-ECM relationship typically believed to present in tumors when compared to …
-
Control of surface structure and properties of responsive hydrogel interfaces via electrostatic interactions
Hydrogels are primary candidates for applications in soft robotics, biomedical devices, and tissue engineering due to their biocompatibility, extremely low coefficients of friction, and potential for a variety of responsive behaviors.[1] Their biphasic nature and viscoelastic network results in a …
-
Evaluation of cellular interactions with functionalized scaffolds for cardiovascular tissue engineering
… step in heart valve tissue replacement surgery. Synthetic scaffolds used in tissue engineering often do not have sufficient cell adhesion, thus the addition of biosignals is crucial. Surface modifications can be used to improve desired cell adhesion and proliferation. To covalently attach cell …
-
Patterning temporally dynamic 4D hydrogel and nanocomposite material gradients: predictive cellular and actuator responses
… actuator (SAA) scaffold. In these, the natural hydrogel alginate (Alg) is integrated with starch-based viscosifying agents as well as the inorganic nanoclay, Laponite XLG (LAP) to prepare a family of hydrogel nanocomposites that are robustly curable under mild conditions (room temperature (RT); …