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Showing 1 to 17 of 17 for “"Synthetic grafts"”.
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A comparative study of common crosslinking agents for electrospun collagen scaffolds
… it difficult to maintain an active life style. Synthetic grafts are used extensively to restore tissue functions. The major drawback limiting successful incorporation of synthetic grafts in body is their lower ability to integrate to natural tissue, poor biocompatibility which often results in …
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Design of an adventitial type reinforcement of prosthetic vascular grafts through mechanically affirmed material and structure modulation
… to produce a successful small diameter synthetic graft. Large diameter synthetic grafts remain patent for extended periods due to high flow rate, while smaller diameter grafts occlude more readily. Mechanical property mismatch between graft and host artery has been cited as one of the …
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Infra-inguinal arterial bypass procedures at Groote Schuur Hospital, 1977-1983 : analysis and evaluation of results
… surgery has centred mainly on the development of synthetic grafts but the perfonnance of autologous saphenous vein has not been bettered in terms of longterm results and cost-effectivity. The initial experience of infra-inguinal bypass at Groote Schuur Hospital, Cape Town, is examined …
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The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models
… a significant need for small diameter vascular grafts to be used in peripheral vascular surgery; however autologous grafts are not always available, synthetic grafts perform poorly and allografts and xenografts degenerate, dilate and calcify after implantation. We hypothesized that chemical …
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Aorto-enteric Fistula Following Abdominal Aorta Surgery
… communications. These factors are: use of homografts, use of nylon grafts, poor vessel suture technic, formation of a hematoma at the suture line, too great porosity of synthetic grafts, infection of the graft, injury of the host vessel. pulsatile thrust of the aorta, redundancy of the grafts, …
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Controlling Tissue Matrix Assembly of Human Mesenchymal Stem Cells toward Engineering Native-like Bone, Cartilage, and Osteochondral Grafts
… These complications include long-term failure of synthetic grafts, inferior success of allografts, and complications from harvesting autografts. The successfully engineered grafts must exhibit biological and structural function similar to that of native tissue in order to withstand physiological …
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
Electrospun Tissue Engineered Vascular Grafts (TEVG) have been synthesized with variable success. TEVG ≤5mm in diameter have had limited success due to poor patency outcomes with high rates of restenosis secondary to a phenomenon called Intimal Hyperplasia (IH). We have performed previous animal …
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Engineering Biodegradable Vascular Scaffolds for Congenital Heart Disease
… in a child’s cardiovascular system, synthetic grafts have been used as a primary intervention. However, current grafts suffer from deficiencies such as minimal biological compatibility, inability to grow and adapt, and high failure rates. Additionally, the grafts are not customized to …
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Design and nondestructive imaging of a bioengineered vascular graft endothelium
… requires bypass surgery using vascular grafts for treatment. Current limitations with fully synthetic grafts have led researchers to bioengineered alternatives that consist of a combination of vascular scaffolds and cells. A major challenge in creating a functional bioengineered vascular …
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Stabilised decellularised vascular grafts in an ovine carotid model
… and coronary artery bypass. Currently available synthetic grafts have unacceptably low patency rates, while autologous saphenous vein grafts are not feasible in one third of patients. Decellularised vascular grafts have been investigated as alternative conduits, but this chemical treatment …
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Numerical simulations of blood flow in arteries using fluid-structure interactions
… bypass surgery (various cases) with natural and synthetic grafts, and (7) to determine the occurrence of intimal hyperplasia following bypass surgery. In the computations, the non-Newtonian behavior of blood was described using the Carreau-Yasuda model. Generally, good agreement between the …
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Electrospun Tissue Engineered Vascular Grafts
ePTFE and Dacron vascular grafts are successful in large diameter applications but provide poor outcomes in small diameter (<6 mm) applications. Occlusion, poor cell ingrowth and a mismatch of compliance compared to the native vessel, cause failure to the current synthetic grafts. Spontaneous …
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Electrospun Tissue Engineered Vascular Grafts
ePTFE and Dacron vascular grafts are successful in large diameter applications but provide poor outcomes in small diameter (<6 mm) applications. Occlusion, poor cell ingrowth and a mismatch of compliance compared to the native vessel, cause failure to the current synthetic grafts. Spontaneous …
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Development of polyHIPE scaffolds for improved bone regeneration
… to donor site complications. We have designed a synthetic scaffold system based on emulsion-templating to create porous scaffolds for bone grafting to address these limitations. These polymerized high internal phase emulsions (polyHIPEs) are biodegradable, maintain strong mechanical properties, …
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Coaxially electrospun heparin-eluting scaffolds for vascular graft application
… scaffolds for small diameter vascular grafts (< 6 mm) has shown promise in the search for alternative solutions, as current synthetic grafts have high failure rates. The inclusion of heparin into such scaffolds can be beneficial for vascular graft applications as it could prevent …
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The effect of scaffold structure and biologic factors on bone regeneration in cap-based scaffolds measured using machine learning
… (HAp) scaffolds are osteoconductive, synthetic grafts that provide an alternative to natural grafts, which have limitations. We and others have fabricated HAp scaffolds with a hierarchical structure that has macropores between orthogonal rods - into which bone can grow, and micropores …
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In vitro endothelialization of vascular prostheses: a possible means to improve the early patency of small diameter vascular grafts
… main reason for the unsatisfying performance of synthetic arterial grafts, we attempted to create an endothelium on the prosthetic surface by lining the graft with cultured endothelial cells. To provide sufficient cell-numbers for lining, a rapid and reliable harvest technique had to be developed …