Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Synthetic glucocorticoids"”.
-
Transgenerational Effects of Synthetic Glucocorticoids on Offspring Behaviour and HPA Development in Guinea Pigs
Glucocorticoids are essential for fetal maturation. However, exposure to high levels of glucocorticoids (i.e. maternal stress/anxiety or synthetic glucocorticoid treatment [sGC]) alters the trajectory of development and increases the risk for chronic diseases later in life. Approximately 10% of …
-
Towards an understanding of synthetic glucocorticoid hazards in aquatic systems.
Synthetic glucocorticoids are pharmaceutical compounds that mimic cortisol, the endogenous ligand ubiquitous to vertebrates and bind to the glucocorticoid receptor within the cytoplasm. Here I examine occurrence of these endocrine disrupting contaminants of emerging concern in surface waters and …
-
Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo
… surge in fetal cortisol and that exposure to synthetic glucocorticoids in premature offspring could accelerate pulmonary maturation, reducing risk of respiratory complications. Ante- and post-natal glucocorticoid therapy has since been demonstrated to significantly reduce morbidity and …
-
The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
… in pregnancy, it is common for women to receive synthetic glucocorticoids (sGC). This thesis has demonstrated that sGC treatment matures the BBB as it increases P-gp and tight junction function. These BECs also display attenuated responsiveness to TGF-β1 stimulation, an effect similar to that …
-
Intergenerational and Transgenerational Effects of Endocrine Insults
… insults – endocrine disrupting chemicals (EDCs), synthetic glucocorticoids (sGCs), and hyperthyroidism – in two different species, humans and mice. EDCs are exogenous substances that interfere with endocrine axes to cause adverse health effects. Humans are ubiquitously exposed to EDCs and recent …
-
Glucocorticoid Receptor Density and Binding Affinity in Horses with Systemic Inflammatory Response Syndrome
… adult horses with SIRS as tissue resistance to glucocorticoids, and potentially relative adrenal insufficiency as well. These results suggest that there are horses with SIRS that might benefit from "physiologic" doses of synthetic glucocorticoids to complement their relative adrenal …