Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Synthetic gene circuits"”.
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Functional Analysis of Synthetic Gene Circuits Controlling A Protein Pump In Yeast
<p>Synthetic biology aims to build biological devices to understand living systems and explore new applications. Synthetic gene circuits such as genetic switches, oscillators and logic gates are at the core of many synthetic biology applications. These gene circuits often include a sensor/regulator …
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Towards dissecting neural ensembles : development of genetic profiling and targeting approaches
The recent development of genetic neural modulation technologies has brought about a renaissance in systems neurobiology, where manipulation of specific neural ensembles coupled with measurements of the resulting behavioral changes have begun to chart the functional organization of the brain. …
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A synthetic positive feedback based gene regulatory circuit
… of reengineering and rewiring of pathways and gene regulatory networks for novel uses, and sometimes for mimicking natural systems for various uses in various disciplines gradually acquired the name “synthetic biology”. Synthetic biology, with foundations rooted in multiple disciplines like …
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Towards extending coarse-grained circuit-host modeling to complex environments
Over the last two decades, synthetic biology has emerged as a critical toolset for genetic engineering. Synthetic gene circuits have been engineered for a variety of uses from functional modules to increasing biosynthetic yield. After decades of showing their potential in labs, synthetic circuits …
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An integrated CRISPR-Cas toolkit for engineering human cells
… immune system that confers resistance to foreign genetic elements including plasmids and phages. Very recently, a two-component CRISPR-Cas technology from Streptococcus Pyogenes comprising of the RNA-guided DNA endonuclease Cas9 and the guide RNA (gRNA) has been demonstrated to enable …
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Cooperative assembly confers regulatory specificity and promotes evolution
… cis-regulatory motifs (CRMs) coordinates precise gene expression in eukaryotes. Complexes of multivalent TRs enable the formation of highly specific regulatory connections between otherwise weakly-interacting, low-specificity molecular components and can be used to engineer regulatory specificity …
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The Role of Gene Expression Noise In Mammalian Cell Survival
… contributing to this problem is cellular heterogeneity. Even in the same environment, cells with identical genomes can display cell-to-cell differences in gene expression, also known as gene expression noise. Gene expression noise can vary in magnitude in a population or in fluctuation time …
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Bistability, Synthetic Biology, and Antibiotic Treatment
… focused primarily on cellular mechanisms that generate bistable switches and their impact on cellular dynamics. </p><p>Here, I study emergent bistability due to bacterial interactions with either synthetic gene circuits or antibiotics. A synthetic gene circuit is often engineered by considering …