Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 1 of 1 for “"Synthetic dosage lethality, Telomerase, hTERT, Tumor heterogeneity, tumor-agnostic therapy"”.
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Targeting Telomerase Overexpression by Synthetic Dosage Lethality
Telomerase reverse transcriptase (hTERT) is upregulated in multiple cancers and accompanied by the evidence suggesting that up-regulation of telomerase expression is linked to tumorigenesis, raised the hypothesis that inhibiting this enzyme is a powerful antitumor strategy. Despite intensive …