Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Synthetic dosage lethality"”.
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Targeting Telomerase Overexpression by Synthetic Dosage Lethality
… cancer treatment. Genetic interactions, such as synthetic dosage lethality can overcome these issues and identify targets that is specific only tumor cells that overexpress telomerase. We used a combination of pooled shRNA and CRISPR screening platforms to comprehensively query the entire human …
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The synthetic dosage lethality between hTERT and DNA damage response associated genes
… directly inhibiting hTERT, this project uses synthetic dosage lethality (SDL) to indirectly inhibit its activity. SDL occurs when the overexpression of one gene becomes lethal, only when combined with the inhibition of another gene (known as the SDL partner). If only one of these two …
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A Novel Platform to Perform Cancer-Relevant Synthetic Dosage Lethality Screens in Saccharomyces cerevisiae
… changes specific to cancer cells. For example, synthetic dosage lethal (SDL) interactions occur when increased gene dosage is lethal only in combination with a specific gene disruption. Since cancer cells often specifically over-express a host of gene products, discovering SDL interactions could …
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Finding the Best Gene Candidate(s) as a Potential Therapeutic Target for N-MYC Overexpressing Neuroendocrine Prostate Cancer (NEPC)
… My master’s thesis aims to apply the concept of synthetic dosage lethality to identify target genes that become essential when N-MYC is overexpressed. Synthetic dosage lethality (SDL) denotes a genetic interaction whereby underexpression of gene A combined with overexpression of gene B results in …
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Mcm10 regulates the turnover of DNA polymerase alpha.
… levels of Cdc17. Furthermore, Cdc17 shows synthetic dosage lethality with not4 cells. Importantly, overexpression of Cdc17 and Mcm10 causes slow growth, an increased mutation rate, and microsatellite-mediated gross DNA rearrangements, suggesting that regulated turnover of Cdc17 is crucial …
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SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS
… trial termination. Genetic interactions, such as synthetic dosage lethality can overcome these issues and identify targets that kill only tumour cells that overexpress polo-like kinase 1. A genome-wide shRNA screen identified 960 synthetic dosage lethal interactions in an inducible polo-like …