Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Synthetic compounds"”.
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Identification & characterization of natural and synthetic compounds as new anticancer agents
… to evaluate the cytotoxicity of potential novel synthetic inhibitors of human cancer cells. Part of the second and all the third year was spent at the University of Cape Town, South Africa, in the laboratory of prof. Ariel Katz under the supervision of proff. Roger Hunter and Catherine H. …
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
… synthesis, and biological evaluation of hybrid compounds as multitargeted anticancer agents. To this extent, an HO-1 inhibitory portion was coupled with different molecules endowed with antitumor activity. Since sigma receptors (sigmaRs) ligands showed potential antiproliferative effects in …
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Cyclization modes in type III polyketide synthases and the synthetic compounds used as probes for mechanistic studies.
… years of research on this family of enzymes. Compounds, thought to be intermediates in these enzyme reactions, have been synthesized and used to probe the enzyme mechanisms. To study the mechanism of resorcinol ring formation catalyzed by STS and ArsB, triketo acids and …
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Part I: Evaluation Of Russian Synthetic Compounds As A Potential Source Of New Drug Leads Agains Breast And Colon Cancer Part Ii: Isolation Of Beta-amyrin Formate From Eucalyptus Viminalis Labill And Investigation Of Its Colon Cancer Activity
… thesis investigates a new source of selective compounds that are potential candidates against cancer. Fifteen Russian compounds were tested in order to establish their efficiency against two types of cancer: human breast SK-Br-3 and colorectal carcinoma HT-29. The bioassay results show that …
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Comparison of dose-dependent outcomes in induction of cytogenotoxic responses by novel glucosyl flavonoids
… neuro- and cardio-protection, etc. Semi-synthetic water soluble quercetin glucosides, maltooligosyl isoquercetin (MI), monoglucosyl rutin (MO) and maltooligosyl rutin (MA) were developed to overcome solubility challenges for improved incorporation in food and medicinal applications. …
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DESIGN OF A SCREENING PROCESS FOR THE DEVELOPMENT
… acids, as well as successful employment of our synthetic compounds. We support our efforts by showing compatibility for binding studies with larger macromolecules. Thus, intrigue remains by the prospects of this project. Challenges within our efforts are highlighted and emphasis is placed on …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… of selective manipulation of the receptors by synthetic compounds on markers of renal damage and structure in an animal model of diet induced obesity (DIO).
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Synthesis of sesquiterpene-tropolones
A modular synthetic platform for the synthesis of the multi-bioactive sesquiterpene-tropolone natural products has been developed in an effort to provide general synthetic access to this class of compounds and related structures. In this work, the convergence of the sesquiterpene and tropolone …
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Synthesis and Evaluation of Tetramic Acids as Antimicrobial Agents
… of the currently available antibiotics, these compounds have potential to serve as a basis for a pharmacophore in synthetic compounds. However, toxicity to eukaryotic cells is frequently a problem with currently known tetramic acids. The purpose of the project, as outlined in the following …
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The Effect of Phytonutrient Supplementation on Pig Growth
… are considered a promising alternative to synthetic compounds to improve animal growth performance. The objective of the study was to examine the effects of varying doses of phytonutrient supplementation on pig growth and metabolism. Thirty-two crossbred pigs (approximately 2 months of age, …
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Removal of Per- and Poly-fluoroalkyl Substances (PFAS) from Water: A Computational Approach
… polyfluoroalkyl substances (PFAS) are persistent synthetic compounds widely detected in the environment due to the exceptional stability of the carbon–fluorine bond, posing significant risks to human health and ecosystems. This dissertation develops a multiscale framework for PFAS remediation and …
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Hindgut secretions in <I> Camponotus pennsylvanicus </I> (De Geer) (Hymenoptera: Formicidae): attractants and nitrogenous excretory materials
… investigated by presenting workers with crude or synthetic hindgut extracts to test for attractancy and trail-following behavior. Chemical analysis was used in conjunction with behavioral bioassays to detect and identify volatiles from the rectal sac, poison, and Dufour's glands. The rectal …
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Analytical and metabolic studies of the trypanocidal diamidines
… and characterized by NMR spectroscopy of the synthetic compounds. The developed method has been applied for the quality evaluation of over one hundred generic samples of diminazene obtained from Sub-Saharan Africa. The results give an indication that the quality of generic formulations of …
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Refinement of the Docking Component of Virtual Screening for PPAR
… are available to control T2D, more efficacious compounds with fewer side effects are in great demand. Drugs targeting PPAR" typically are compounds that function as agonists toward this receptor, which means they bind to and activate the protein. Identifying compounds that bind to PPAR" (i.e. …
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New Approaches to the Development of Peptoid Vaccines
… large one-bead-one-compound libraries of synthetic compounds with monoclonal antibodies that have already been shown to be broadly protective against a toxin or pathogen would allow the identification of mimetic B cell epitopes. For this platform, peptoids were chosen to construct …
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Fundamental Investigations of Mechanistic Pathways of Selected Organic Reactive Intermediates
… aromatic substitution. Using commercial and synthetic compounds of varying it-electron density, the fact that % -complexes actually exist in these species was determined by a mass spectral investigation that was designed to monitor alkyl side-chain isomerizaitons. Also, the amount of …
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Application of Pd Catalyzed Alkylation: Synthesis of Bicyclic Furans, Isoxazolines and New Cyclopentane Amino acid Analogs
… in the last decade to obtain enantiopure compounds. The main emphasis of this work is to utilize Pd catalyzed allylic alkylation to synthesize new heterocycles including furans, isoxazolines and new cyclopentane amino-acid analogs in an enantioselective manner. The stereochemical outcome …
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Defining the Host Genetic Control of the Barley Rhizosphere Microbiota
… uncouple profitable crop yield from the input of synthetic compounds in the agroecosystem. In the last decade technical advances have allowed scientists to gain unprecedented insights into plant-microbiota interactions in the rhizosphere. <br/><br/>However, a precise understanding of how plants …
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ANTIFUNGAL ACTIVITY OF NATURAL AND NATURAL-INSPIRED BIOACTIVE COMPOUNDS TO CONTROL THE RICE BLAST FUNGUS
… and development of natural and nature-inspired compounds as multitarget biofungicides, aiming to interfere with essential cellular processes and fungal virulence mechanisms. A series of natural stilbenoids, including monomeric (deoxyrhapontigenin, pinostilbene, DMHS) and dimeric compounds were …
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Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs)
… properties seen with cannabinoid synthetic compounds SMM-189 (CB2 selective inverse agonist), HU308 (CB2 selective agonist), and the endocannabinoid anandamide (AEA) in periodontal disease. Our primary investigation led us to evaluate the most potent stimuli for the study, from …
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