Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 310 for “"Synthetic biology"”.
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Synthetic biology for food applications
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Bistability, Synthetic Biology, and Antibiotic Treatment
… due to bacterial interactions with either synthetic gene circuits or antibiotics. A synthetic gene circuit is often engineered by considering the host cell as an invariable "chassis". Circuit activation, however, may modulate host physiology, which in turn can drastically impact circuit …
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Foundational platform for mammalian synthetic biology
The emergent field of synthetic biology is different from many other biological engineering efforts, in that its roots, design principles, and forward engineering perspective have been adopted from electrical engineering and computer science. Synthetic biology is uniquely poised to make great …
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GenoCAD: linguistic approaches to synthetic biology
Synthetic biology is an emerging interdisciplinary research field, which leverages the maturation of DNA synthesis technologies. By introducing engineering principles to synthetic biological systems design, synthetic biology shows great potential to shed new lights on biology and benefit human …
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Harnessing AI/ML for advancing synthetic biology
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Controlled Hybrid Material Synthesis using Synthetic Biology
… artificial gene regulation, achievable through synthetic biology, allows for an additional dimension of the control of hybrid material function. Here, I genetically engineer E. coli with a tightly controlled artificial protein construct, allowing for inducible expression of different amounts of …
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Improving Bacterial Therapeutics and Diagnostics through Synthetic Biology
… of recombinase function and expanded the synthetic biology toolbox, and it can enable rational tuning of the response dynamics of bacterial diagnostics and the pharmacokinetic profile of bacterial therapeutics. Second, we engineered Escherichia coli to sense extracellular proteins. A …
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Natural products discovery and characterization via synthetic biology
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2014-04-09T15:17:47Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Luo_Yunzi.pdf: 5368178 bytes, checksum: 2f5db8aedc8b652c3a2b8138ab840a22 (MD5)
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Building a robust bacterial chassis for synthetic biology
… GASP phenotype could serve a robust chassis for synthetic biology because of the beneficial adaptations it acquires.
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Tools for RNA and cell-free synthetic biology
Amid the myriad recent developments in synthetic biology, progress has been fastest in the areas with the most versatile tools for understanding and engineering biological systems. RNA synthetic biology and synthetic minimal cells are areas where design is limited by the availability of tools to …
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Synthetic biology approaches for engineering diverse bacterial species
… or materials by initiating expression of biosynthetic pathways in response to specific signals. In this thesis, two new genetic tools were developed to aid the construction of genetic circuits and facilitate their delivery to bacteria isolated from diverse environments. First, antisense …
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Retroactivity, modularity, and insulation in synthetic biology circuits
A central concept in synthetic biology is the reuse of well-characterized modules. Modularity simplifies circuit design by allowing for the decomposition of systems into separate modules for individual construction. Complex regulatory networks can be assembled from a library of devices. However, …
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Combating biofilms and antibiotic resistance using synthetic biology
… biofilms and antibiotic resistance using synthetic biology. To remove biofilms, I engineered bacteriophage to express a biofilm degrading enzyme during infection to simultaneously attack biofilm cells and the biofilm EPS matrix. These enzymatically-active bacteriophage substantially …
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User-centered automation process in synthetic biology research
By designing and re-designing biological system, synthetic biology is advancing a wide range of domains from biotherapeutics for fatal cancers to biofuels and artificial meat to improve the global environment and food security. As the scale and complexity of synthetic biology endeavors are …
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Developing New Modalities for Biosensing using Synthetic Biology
… living cells. By leveraging the tools of synthetic biology, a genetic circuit was designed, constructed, and inserted into bacteria for enhanced biotin biosynthesis in vivo. Upon induction, a 17-fold increase in biotin production was measured in the engineered cells in comparison to wild …
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Genetically encoded division machinery for cell free synthetic biology
… inside of water-in-oil emulsion compartments and synthetic phospholipid vesicles. The system was built with DNA and purified transcription and translation machinery housed in a compartment. A particular emphasis was placed on FtsZ, a protein that oligomerizes into a ring at the midcell and splits …
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Synthetic Biology for Autotrophic and Heterotrophic Production of Ethanol
… showed only a marginal increase photosynthetic activity and a decrease in growth rate. Additional genetic manipulation would be required to alleviate bottlenecks and toxic intermediates in order to create a fully functioning supplementary CO<sub>2</sub>-fixation pathway in …
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Biohydrogen production in Escherichia coli – a synthetic biology approach
… and to achieve this goal a number of alternative synthetic biology approaches were investigated. A synthetic [FeFe]-hydrogenase based on a thermostable NADH-dependent hydrogenase was designed, constructed and expressed in E. coli. The structure and activity of the synthetic hydrogenase has been …
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