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Showing 1 to 20 of 50 for “"Synthetic Organic Chemistry"”.
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Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry
Cationâ Ï interaction is an important determinant in protein structure and function. Among the three proteinogenic aromatic amino acids, tryptophan (Trp) is the strongest cationâ Ï donor. We reported the asymmetric syntheses of tryptophan regioisomers in which the amino acid side chain is attached …
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The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics
… A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. One of the most potent agonist is quisqualic acid (69), and this thesis features two aspects of the synthetic organic chemistry and the …
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2-Silicon-Substituted 1,3-Dienes: Participants in Diels-Alder Chemistry and Metal-Mediated Processes
Two of the major focuses in current synthetic organic chemistry are asymmetric carbon-carbon bond forming processes and catalytic one-pot reactions. Two processes that are of interest to our research are the Diels-Alder reaction and transition-metal-catalyzed cross-coupling reactions. Issues that …
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Addition Reactions or Diethyl 2,4-dicyanoglutaconate
For many years, acrylonitrile has afforded the organic chemist a convenient method of introducing a three-carbon residue onto a variety of organic compounds by the so-called cyano-ethylation reaction. This reaction is generally brought about by a base-catalyzed, nucleophilic addition. The purpose …
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Brønsted acid-catalyzed reaction of alkynyltrifluoroborates with acetals and ketals
… carbon-carbon bonds is of great importance in synthetic organic chemistry. Brønsted acid catalysis is a powerful synthetic tool to make many different compounds, however, the current carbon-based nucleophiles are the major limitation of acid-catalyzed reactions. In effort to expand repertoire …
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Transition Metal-Catalyzed Preparation and Functionalization of Nitrogen-Containing Heterocycles
… single most fundamentally important operation in synthetic organic chemistry. Arguably, the aldol and Diels-Alder reactions stand as the most significant advances in forging linkages between carbons of an sp3-hybridized nature. Beginning in the early 1970s, seminal advances were made with respect …
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Mechanistic Studies of Donor-Acceptor Cyclopropanes
… useful reactions is opened up. This allows the chemistry to be better utilized, providing easier access to important molecules when needed, and contributes to advancing the field of synthetic organic chemistry. In addition, cyclobutane 1,1-diesters were also investigated as a source of …
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Chiral acyl radicals generated by visible light enable stereoselective access to 3,3-disubstituted oxindoles: application toward the synthesis of (–)- and (+)-physovenine
… tools for carbon-carbon bond formation in synthetic organic chemistry. Such species can be formed in an efficient and environmentally friendly manner by way of photoredox catalysis, which uses a photocatalyst in conjunction with visible light (typically) to generate the necessary …
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Cascade Transformations in Organic Synthesis: I. The Interception of Carbene Alkyne Metathesis Intermediates II. Photo-Activation of Hydrazones III. Organocatalyzed Cascade Conjugate Addition/Aldol Annulation of Organoboronates
… in constructing complex building blocks in synthetic organic chemistry. It includes the interceptions of carbene alkyne metathesis intermediates, boron enolate intermediates, fused cyclopropene intermediates, and boronic acid intermediates. First, the multi-alkyne carbene cascade reaction …
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Towards a Formal Total Synthesis of Triptolide Via a Gold-catalyzed Cyclization Cascade
… transformations are an emerging field in synthetic organic chemistry, but their efficacy and potential uses are gaining much recognition among the synthetic organic community. Our research group is extremely interested in the applications of such gold-catalyzed organic transformations in …
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I. Microwave-Influenced Diversity-Oriented Synthesis Of Biologically Relevant Small & Natural-Product-Like Molecules Via Multicomponent Coupling Reactions Ii. Synthetic Studies Toward The Total Synthesis Of The Repeating Tetrasaccharide Unit Of Zwitterionic Polysaccharide Ps A1
… useful in carbohydrate as well as other areas of synthetic organic chemistry. Additionally, the new p-N,N-diemethylaminobenzyl (PDMAB) PG was employed to develop an alkoxide-based neutral glycosylation and further extended to study entirely neutral glycosylation via oxocarbenium ion.</p> <p>We …
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Palladium-Imidazolium Carbene Catalyzed Heck Coupling Reactions and Synthesis of a Novel Class of Fluoroanthracenylmethyl PTC Catalysts
… of carbon-carbon bond formation. This standard synthetic method has been developed to a high level of utility using various catalysts, conditions and substrates. Yet significant drawbacks remain, including poor reactivity, the need for high temperatures and base, limited substrate generality, …
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Synthesis and Biosynthesis of Polyketide Natural Products
… of a large and broad chemical spectrum, synthetic organic chemistry and biochemistry have found in the last two decades a fertile common ground in the area pertaining to the biosynthesis of natural products. Both disciplines remain indispensable in providing unique solutions on numerous …
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Synthetic and computational investigations into reaction pathways towards complex heterocyclic ring systems
… four nitrogen atoms. The development of new synthetic routes to novel heterocyclic systems has remained a critical branch of synthetic organic chemistry due to potential applications in biomimetics and pharmaceuticals, such as dyes and explosives. 1,2,3,5-tetrazocines were originally proposed …
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Synthetic coenzymes for in vitro selection of DNA enzymes.
… solubility, binding, and catalytic power. These synthetic coenzymes were included in combinatorial selection experiments aimed at isolating coenzyme-dependent deoxyribozymes from a randomized pool of DNA. Kinetic analysis of deoxyribozymes obtained in these experiments showed a rate enhancements …
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EXPLORING UNPRECEDENT SYNTHETIC ROUTES FOR CHIRAL AMINO DERIVATIVES
… focuses on the development of unprecedented synthetic strategies for the preparation of chiral amino derivatives through the integration of photoredox catalysis, organocatalysis, transition-metal catalysis, and continuous-flow chemistry. The work explores the synthetic potential of …
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Chirality directed self-assembly: in situ construction of recyclable and reusable Janus dendrimers
The underlying theme at the forefront of synthetic organic chemistry has always been about compounding simple precursors into more complex molecular targets. However, this strenuous process often involves the generation of toxic and hazardous waste. In order to move towards a more sustainable …
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Investigating asparagine-linked glycosylation substrate : specificity and effects on protein folding
… Research discussed in this dissertation applies synthetic organic chemistry to probe this important biological system. To study the effects of N-linked glycosylation on protein folding, a semi-synthetic strategy was developed to access a set of model proteins that were homogeneously glycosylated …
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ADVANCES IN THE DIRECTED ORTHO METALATION, SUZUKI-MIYAURA CROSS COUPLING, AND RING-OPENING REACTIONS OF INDAZOLES. SYNTHESIS OF LUMINESCENT ACRIDINE AND NOVEL INDAZOLE-BASED OXAZABORINES
… reactions, has led DoM into the modern age of synthetic organic chemistry. Chapter one of this thesis begins with a brief review of traditional approaches for the carbon and nitrogen functionalization of indazoles and the reactivity challenges faced therein. This is followed by a comprehensive …
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Studies on the residue chemistry of some organophosphorus pesticides
The plan of working has involved synthetic organic chemistry and analytical chemistry related to specific studies on two organophosphorus pesticides, viz. Q, Q-diethyl -(K-ethosycarbonyl-8-methylcarbamoylmethyl) phosphorodithioate (common name mecarbam) and 0, G-diethyl S-chloromethyl …
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