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Showing 1 to 20 of 67 for “"Synthetic Methodology"”.
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Novel synthetic methodology employing organosulfur chemistry in the synthesis of chalcone derivatives
… a-thio-b-chloroenones are extremely useful synthetic intermediates. Their formation through a N-chlorosuccinimide (NCS) mediated chlorination cascade is a powerful synthetic methodology which transforms an unreactive sp3 b-carbon into a highly reactive sp2 b-carbon.a-Thio-b-chloroenones have …
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Advances in synthetic methodology: Dearomative aminofunctionalization of arenes and high-throughput reaction discovery
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Palladium (II) Mediated Transformation: Exploring Synthetic Methodology for the Synthesis of Cyclopentenones from Tertiary-Cyclobutanois
A new method for the synthesis of ring-fused cyclopentenone is described. The method utilizes the built-in strain of tertiary cyclobutanol to drive the palladium(II)-catalyzed rearrangement to the corresponding ring-fused cyclopentanone followed by Saegusa-Ito reaction to furnish final …
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Synthetic Methodology and Application of Enamine [2+2] Cyclisations for Cyclobutane Synthesis. Development of Integrin Antagonists as Anticancer Therapeutics Towards a Total Synthesis of Providencin
… antagonism and potential benefit of this. Synthetic studies towards the marine natural product providencin has led to the development of a previously unknown intramolecular enamine [2+2] cyclisation which has been shown to proceed in a diastereoselective manner. This reaction has been …
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Novel synthetic methodology employing transition metal catalysed reactions of α-diazo-β-keto sulfonamides and α-cyano-α-diazoacetates; the impact of substituents on the reaction pathway
The central focus of this thesis is the reactivity of α-diazo-β-keto sulfonamides, α-cyano-α-diazoacetates and α-arylsulfonyl-α-diazoacetates employing rhodium and copper catalysts. While the α-diazo-β-keto sulfonamides were specifically designed to investigate rhodium- and copper-catalysed …
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Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents
… a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the …
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Structure elucidation and studies relating to the synthesis of plasmalopentaene-12
… the name plasmalopentaene-12 was coined. Synthetic methodology was developed for obtaining synthetic plasmalopentaene12. This was necessary in order to confirm the structure and to determine the precursor's biological role. The synthetic methodology proceeded through a novel "acyl …
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1. C-C Bond Formation via Soft Enolization and Umpolung-like Chemistry 2. Electrophilic Fluorination of Organozinc Reagents
Synthetic methodology development towards convenient C-C bond and C-F bond formation is a desirable synthetic tool for industry and academia. Using commercially available substrates towards chemical transformations is often a strategy used to simplify the process of synthesizing compounds. This …
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Synthesis Of Natural Product-Based Sphingosine Derivatives
… available cinnamyl alcohol. The described synthetic methodology is proficient and scalable for the synthesis of fully substituted azetidines. We were successful at preparing two azetidine analogs, (±)-30 and (±) -31, via an intramolecular Mitsunobu reaction as a key step. Another crucial …
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Synthesis and Complexation Studies of Heterocyclic Compounds With Two or Three Contiguous Hydrogen Bonding Sites
… hydrogen bonding sites is described. A general synthetic methodology was developed to produce 5-substituted anthyridine analogs. These compounds exhibited increased stability over the unsubstituted anthyridines. A novel hydrogen bond donor-donor-acceptor (DDA) unit was synthesized to mimic the …
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DEVELOPMENT OF SYNTHETIC METHODOLOGIES TOWARDS CYCLIC HYDROXAMIC ACID-BASED NATURAL PRODUCTS
… Our research targets to develop new synthetic methodology towards making cyclic hydroxamic acids in a stereoselective and regioselective fashion. Basic decomposition of Piloty's acid transforms cyclic ketones (mainly four and five membered) into ring-expanded cyclic hydroxamic acids …
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Towards the total synthesis of Phacelocarpus-2-pyrone A: Novel 2-pyrone chemistry
… A and the development of novel synthetic methodology for the synthesis of functionalised 2-pyrones. Initial studies focused on the synthesis of the natural product and the applications of Pd-catalysed cross-coupling reactions using the interesting palladium catalyst, CatCat. Key …
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Synthetic Methods for the Preparation of 1,3-S,O-Esters, α-Phosphonovinyl Triflates, and α-Alkynylphosphonates
<p>A broad and systematic study was conducted on synthetic methods to efficiently synthesize 1,3-<em>S</em>,<em>O</em>-esters, α-phosphonovinyl triflates, and α-alkynylphosphonates under mild reaction conditions. The master’s thesis is composed of two projects; the first project is titled …
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Single-Step Biofriendly Synthesis of Surface Modifiable, Near-Spherical Gold Nanoparticles for Applications in Biological Detection and Catalysis
… warrant reliable, viable, and biofriendly synthetic methodology for GNPs with homogeneous sizes and shapes, particularly sizes above 30 nm, which is currently challenging. In the present study, an environmentally benign, biofriendly, singlestep/ single-phase synthetic method using dextrose …
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Chiral alkaloid derivatives: Synthesis and medicinal chemistry applications
… has been achieved. Herein we present the synthetic methodology, structural characterisation and biological evaluation of these novel opioid species. A range of opioid derivatives with modification at the 6 position to form linked bis-opioid species were successfully synthesised. The …
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POLYMER ORGANIC SEMICONDUCTORS AND THEIR DEVICES
… discussed in their respective devices. Firstly, synthetic methodology based on Suzuki coupling for generation of high molecular weight polymers is discussed using well-known fluorene-containing-polymers. Next, different molecular weight high-performance diketopyrrolopyrrole-based co-polymer was …
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Improved synthesis and application of planar-chiral nucleophilic catalysts in asymmetric reactions and copper-catalyzed enantioselective N-H insertion reactions
… catalysts. Using planar-chiral catalysts, two synthetic methodology projects have been developed: Chapter 2 describes the first asymmetric synthesis of trans P-lactams, and Chapter 3 describes the asymmetric synthesis of tertiary a-chloroesters. In the chapter describing the asymmetric …
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I SYNTHESES OF SELECTIVELY FUNCTIONALIZED 9(ANE)NITROGEN(3) AND 12(ANE)NITROGEN(3) CYCLIC TRIAMINES II SYNTHESES, COMPLEXATION, AND CONFORMATIONAL STUDIES OF SOME AZAPODANDOCORONANDS (TRANSANNULAR, TRICYCLICORTHOAMIDE, AMIDINIUM SALTS)
… effects and transannular interactions. The synthetic methodology by which these compounds provide routes to selectively protected cyclic triamines is discussed relative to the preparation of selectively functionalized azapodandocoronands and other compounds of interest.</p><p>Precedent for …
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Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
… and norepinephrine. A short and efficient synthetic methodology was developed for the synthesis of unique compounds which could exhibit potency for both the dopamine and serotonin transporters. The 3ƒÀ-aryl-3ƒ¿-(4Œ, 4-disubstituteddiphenylmethoxy)tropane analogues were designed as hybrid …
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