Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Synovium"”.
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Comparative osteogenesis of equine mesenchymal stem cells isolated from bone marrow, adipose tissue, and synovium
… osteogenic potential of equine MSCs derived from synovium, bone marrow, and adipose tissue maintained under the same culture conditions. Equine MSCs were isolated from synovium [SYN], bone marrow [BM] and adipose tissue [AD], expanded in monolayer culture for two passages, and then transferred to …
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Expression of alpha-smooth muscle actin and contraction of collagen-glycosaminoglycan scaffolds by cells derived from canine synovium
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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Development of a gamma ray telescope for online synovial dosimetry in boron neutron capture synovectomy
… knowledge of boron dose delivered to the synovium is necessary so that the remaining irradiation time can be determined. A 478 keV photon is emitted following 94% of boron neutron capture reactions, and detection of 478 keV photons emitted from the synovium provides a potential approach …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… inflammatory disease primarily affecting the synovium, articular cartilage, and bone within a joint, but it is a unique form of arthritis wherein effects are systemic. The cause of this autoimmune disease remains unknown, but there are many environmental and genetic factors that play into …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… used to determine whether factors within the synovium could modulate HERVs, resulting in their upregulation. Exogenous viral protein expression and pro-inflammatory cytokines were shown to exert a significant modulatory effect over HERV-K (HML-2) transcription. From this data, it is clear that …
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Chondrogenic capacities of equine synovial progenitor populations
… capacities of MSCs isolated from equine synovium (SYN), bone marrow (BM) and adipose (FAT) tissue, six healthy adult horses were used in this study. BM aspirates were collected from tuber coxae, SYN tissues were collected from right radiocarpal joint, and FAT tissues were collected from …
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Somatic Mutations in Ageing and Degenerative Disease
… sequencing. Using these results we show that the synovium is a mostly polyclonal tissue with the capacity for large clonal expansions. We explore how the histopathology of rheumatoid arthritis and osteoarthritis relates to driver mutations, clonal expansions, and immune infiltration. Using …
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Elucidating the Relationship Between Macrophages and Synovial Mesenchymal Progenitor Cell Chondrogenesis
… cartilage and joint tissues. Macrophages in OA synovium contribute to the inflamed joint environment by releasing inflammatory mediators promoting cartilage loss. What remains unknown is how macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs are able to …
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Zellbiologie der Knochenresorption
… ausgeprägt. Angesichts ihres hohen Anteils im RA Synovium sowie im PL Gewebe und des langsamen Krankheitsverlaufs, spielen aktivierte Fibroblasten möglicherweise eine wichtige Rolle bei der Knochendestruktion, die bei der Entwicklung neuer Therapiestrategien berücksichtigt werden sollten.
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Rheumatoid arthritis and atherosclerosis: common pathogenic mechanisms explored
… monocytes co-localise with CX3CR1 in human RA synovium, providing further evidence of the chemotactic effects between monocytes and the FKN/CX3CR1 axis and the significance of CX3CR1 in RA pathogenesis. Finally, I describe an association between seropositive RA and soluble Glycoprotein VI …
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Inflammatory and Immune Effects of Intra-Articular Mesenchymal Stem Cells in Horses
… groups. Arthroscopic examination revealed normal synovium with no grossly detrimental effect to the synovium or cartilage. Synovial histology demonstrated significantly increased inflammatory cells, lymphocyte perivascular cuffing and bone morphogenetic protein 2 antibody uptake for MSC injected …
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Changes in 3 Dimensional Microstructures of Subchondral Cancellous Bone of Distal Femur in Early Osteoarthritis
… by subchondral cancellous bone, ligaments, and synovium. This study was designed to explore what changes occurs in subchondral cancellous bone in early osteoarthritis and find out the relation between cartilage damage and microstructural changes of cancellous bone. MATERIALS & METHODS: Total of …
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Harnessing the Regenerative Characteristics of Meniscus Superficial Zone Cells
… a subset of genes consistent with the adjacent synovium. These cells also show a decreased response to changes in microenvironmental stiffness and generate lower traction forces but migrate faster and proliferate at higher rates in low-stiffness environments compared to body cells. Notably, in …
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… induced uniquely in fibroblasts derived from teh synovium. Different signalling pathways mediated the secretion of those mediators. IL-6 release depended on MAP kinases p38, ERK and JNK as well as NFkB transcription factor, whereas CCL5 production required PI3/Akt and NFkB
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Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis
… for maintaining joint health, specifically the synovium. Previous research from the Appleton lab has shown that efferocytosis, the process for the clearance of dead and dying cells by macrophages, is impaired in OA patients. This project further explored the OA-specific mechanisms controlling …
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An in Vitro Microenvironment for Nucleus Pulposus Regeneration
… differentiation capacity. Specifically, synovium derived stem cells (SDSCs) have a higher chondrogenic capacity compared to stem cells derived from other tissues. Another advantage and potential use of SDSCs is that they can produce decellularized extracellular matrix (DECM); expansion of …
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T cell Immunomodulation in the Lymph Node for Inhibition of Load-Induced Osteoarthritis
… and decreased localization of T cells in the synovium. Furthermore, the absence of T cells, but not γδ+ T cells (TCRα-/- mice), reduced cartilage degradation and osteophyte formation. Lastly, we engineered and assessed the in vivo efficacy of an injectable, protease-degradable PEG-4MAL …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… the capacity to produce viral particles in RA synovium. This study set out to explore how HERV-K10 Gag matrix region could contribute to RA pathogenesis and perpetuation, with particular emphasis on its ability to mimic host autoantigens. We showed that Gag region exhibits high levels of …
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Advanced Magnetic Resonance Imaging of Osteoarthritis
… study where the utility of MR QIBs of synovium, subchondral bone and cartilage in experimental medicine studies is assessed. In summary, this thesis will inform decisions regarding the use of MR-based QIBs in future longitudinal and interventional studies. Their inclusion in …
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A Systems-Based Approach to Examine the Molecular Basis of Interactions between Human Monocytes and Human Micro-Vascular Endothelium
… cases, endothelial cells were isolated from RA synovium and characterised by gene expression microarray. These data showed that similar cellular pathways are up-regulated by RA synovial endothelium and micro-vascular endothelium under in vitro inflammatory conditions.<br/>In the third step, …
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