Global ETD Search
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Showing 1 to 6 of 6 for “"Synovial Inflammation"”.
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Equine Septic Arthritis and Serum Amyloid A
… diagnosed primarily based on clinical signs and synovial fluid cytology. Septic synovial fluid is characterized by significant elevations in total protein (TP) and total nucleated cell count (TNCC). However, in some cases it can be difficult to distinguish between septic arthritis and non-septic …
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Estrogen and 2-methoxyestradiol: regulation of arthritis, inflammation and reactive oxygen species
… arthritis (RA) is characterized by severe synovial inflammation, cartilage destruction, and immune-mediated bone loss. Estrogen ameliorates experimental RA, reducing both inflammation and bone loss. The inflamed tissues are damaged partly by innate immune cells producing reactive oxygen …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
<p>Synovial tissue fibrosis is an immune mediated disease characterized by fibroblast cell migration, proliferation and transition to a myofibroblast phenotype characterized by alpha smooth muscle actin (a-SMA) upregulation and stress fiber formation. Transforming growth factor-β (TGF-b) plays an …
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Viral Delivery of the Fat-1 Gene to Treat Post-Traumatic Arthritis with Diet-Induced Obesity
… of the Fat-1 enzyme showed protection from synovial inflammation and osteophyte formation, while administration of Luciferase did not confer protection. These findings suggest the utility of gene therapy to deliver the Fat-1 enzyme, which has potential as a therapeutic for injured obese …
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Investigations into the role of Toll-Like Receptors in the modulation of the inflammatory response during Osteoarthritis
… and endogenous alarm signals contained in the OA synovial fluid (SF), plays a key role in OA and this was confirmed by neutralisation of TLR3 expression which shifted the balance from pro-inflammatory to an anti-inflammatory cytokine milieu. Next using a proteomic approach, we found that …
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Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis
… primary blood monocytes, which were treated with synovial fluid from patients with high levels of inflammation due to knee OA. By feeding labeled apoptotic cells to macrophages stimulated with synovial fluid and fixing the cells during the process of efferocytosis, we were able to identify the …