Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Synergistic toxicity"”.
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Development and analysis of an in vitro model of inflammatory cytokine-mediated idiosyncratic drug hepatotoxicity
… in large sample populations. Drug-induced hepatotoxicity, occurring in a very small fraction of patients, poses a major challenge to pharmaceutical companies due to its unknown mechanism(s) of action and deficient models for study. In vitro model systems may have the potential to predict this …
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The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma
… mediated NAD+ depletion and combination led to synergistic toxicity. These results identified NQO1 expression as a potential marker of susceptibility to β-lapachone. We next investigated targeting of ribose synthesis, the basic building block for nucleotide synthesis, as a mechanism for global …
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Langfristige Entwicklung Zytostatika-induzierter Nierenfunktionsstörungen bei pädiatrisch-onkologischen Patienten
Nephrotoxicity is a frequent complication of chemotherapeutic treatment. The aim of the investigation is to analyse the long-term nephrotoxic sequelar in patients with malignancies. Using optimized sodium dodecyl sulfate polyacrylamid gel electrophoresis (SDS-PAGE) even in proteinuria < 150 mg/day …
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The iron-dependent cyanide and hydrogen peroxide co-toxicity in Escherichia coli and its catastrophic consequences for the chromosome
… invading microbes. NO potentiation of H2O2 toxicity is a known bactericidal weapon employed by macrophages. In fact, in human neutrophils activated by bacterial infection, the myeloperoxidase enzyme catalyzes the formation of hydrogen cyanide (HCN) from serum thiocyanate (SCN-). In the past, …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
… drug delivery carriers can reduce systemic toxicity caused by off-target interactions, increase drug solubility and stability in physiological fluids, and improve efficacy through enhanced targeting and intracellular delivery to cancer cells. Layer-by-layer nanoparticles (LbL NPs) are …
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The combined toxic effect of nanoparticles and lead in the presence of algae (Raphidocelis)
<p>"The elevated toxicity of toxic metals in the presence of nanoparticles (NPs) has raised significant concerns on the NP environmental safety. This research focuses on the impact of environmental conditions, specifically algae, on this type of toxicity. An indicator aquatic organism, …