Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Synergistic interactions"”.
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GDF9 and BMP15: species difference and synergistic interactions.
… species difference of the proteins, GDF9/BMP15 interactions and the presence of post-translational modifications. However, factors such as species difference and post-translational modifications have yet to be investigated in terms of their effects on GDF9/BMP15 interactions. The aims of this …
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Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome
… of Dube3a, and Dube3a and HERC2 interact synergistically to impact phenotypes associated with Dup15q syndrome in vivo. Data presented in Chapter 3 suggests that genes other than UBE3A are important in generating the Dup15q phenotypes and should not be ignored when modeling Dup15q syndrome. …
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Effects of a dual application of entomopathogenic nematodes and entomopathogenic fungi against a forest pest, Hylobius abietis L. (Coleoptera: Curculionidae) and a horticultural pest, Otiorhynchus sulcatus F. (Coleoptera: Curculionidae)
… of single dose applications, inferring a synergistic effect. However, combinations of these pathogens may also result in additive or antagonistic interactions which would be of no benefit to growers. Hylobius abietis (large pine weevil) and Otiorhynchus sulcatus (black vine weevil) cause …
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A novel bioengineering platform using functionalized self-assembly peptides to enhance CYP3A2 activity in modified rat hepatocyte sandwich cultures
… extracellular matrix and disconnected from the synergistic interactions between other hepatic cells types further exacerbate hepatocellular function. This study aims to improve hepatospecific activity, especially CYP3A2 - a biomarker that is notoriously known to quickly lose expression in …
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Development of Novel Synergistic Therapeutic Strategies to Combat Antimicrobial Resistance: Critical Roles for Natural Products
… compounds inhibit a range of pathogens and can synergistically enhance the antibiotic susceptibility of AMR bacteria, indicating that EO-antibiotic combinations could extend the utility of antibiotics. The antimicrobial activity of cumin, oregano and rosewood EOs was determined against …
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Targeting DNA Repair in Prostate Cancer: Therapeutic Combinations & Disease Models
… on cell viability was profiled, highlighting synergistic interactions between the AR signalling inhibitor Enzalutamide (Enza) when combined with either PARP inhibitor Olaparib or ATM inhibition (ATMi). Olaparib and Enzalutamide combination treatment were determined to transcriptionally …
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Developing novel drug combinations for treatment of invasive fungal infections
… its resistance in C. auris. Furthermore, the synergistic interactions of these combinations were applied on other medically important Candida, Cryptococcus, and Aspergillus species. In a comprehensive mechanistic study, we discovered that lansoprazole interferes with an essential target in the …
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An ethnobotanical and antidiarrhoeal investigation of plants used traditionally in the Maputaland area homesteads
… Some aqueous extracts in combination showed synergistic interactions. The combination of Acanthospermum glabratum with Krauseola mosambicina showed (76%) synergistic interactions when investigated in various ratios. The results from this study correlates to a certain extent with the use of …
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Ecological implications of allelopathic interferences with reference to Phragmites australis
… modes of action, interactive effects, and synergistic interactions. For allelopathy to be implicated as a mechanism that facilitates invasion, multiple aspects of the plant species allelopathic properties must be examined. This research investigated allelopathy as a mechanism of the …
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The design, characterization, and application of CRISPR-based tool in human cells
… mammalian metabolic engineering, and identifying synergistic interactions of endogenous proteins in situ.
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Investigations on the antifungal and cancer modulating properties of extracts from selected species of Tulbaghia
… growth inhibition responses were produced. More synergistic interactions were observed for the combinations of sporekill with T. violacea (62%) and T. alliacea (75%) than for T. simmleri (25%) .. Mixtures between the azole fungicides and T. simmleri produced 94 % synergistic interactions. …
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Characterization and modeling of the effect of environmental degradation on flexural strength of carbon/epoxy composites
… stress. The hygrothermal conditions capture the synergistic effects of field exposure and extreme temperatures, viz., hot/dry, hot/wet, cold/dry, and cold/wet. Short term tests were performed to determine the flexural strength of environmentally aged composite specimens in accordance with ASTM …
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Effects of alloying elements upon austenite decomposition in high strength low alloy steels
… of transformation stasis was explained by synergistic interactions among alloying elements. The paraequilibrium model was applied to calculate the metastable fraction of ferrite in each alloy. This fraction was shown to coincide with cessation of transformation in the Mo alloy transformed …
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Association of lingual myoarchitecture with local mechanics during swallowing determined by magnetic resonance imaging
… during swallowing. In order to observe the synergistic interactions of the eight different muscles in the tongue, MRI techniques were used to determine the three-dimensional fiber architecture, measure the mechanical function of the tongue during swallow, and relate the two quantitatively to …
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Oil palm phenolics suppresses oxidative stress and inflammation
… mixture led to the experiments for probing the synergistic interactions and biological enhancement activity among the individual components of OPP by using chemical and cell-based assays. The results described in this thesis include several advancements towards the goal of manufacturing process …
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Tailored heterogeneous catalysts for biomass conversion
… surface is investigated, demonstrating how these interactions drive catalytic efficiency and selectivity. This work sheds light on the intricate connections between catalyst design, surface structure, and functional performance, offering new insights into how tailored catalysts can be leveraged to …
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Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level
… subtypes of these receptors can lead to synergistic inhibition of pain signaling. Understanding how these receptors interact at the cellular level may provide insight into how to exploit such mechanisms for improved pain management strategies. This thesis has taken two approaches to …
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Investigation of ciprofloxacin antibacterial combinations.
… In a number of cases, potentially important synergistic interactions were demonstrated. S. aureus and P. aeruginosa mutants resistant to the antibacterials alone or in combination were selected in vitro. Stably resistant mutants of both organisms were isolated. The greatest propensity for the …
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Mapping Genotype to Phenotype with High-Throughput Empirical Approaches
… between mutations, we find key sites with strong synergistic interactions that explain the strikingly different patterns of breadth in the two antibody libraries. These features of the binding affinity landscapes strongly favor sequential acquisition of affinity to more diverse antigens. At the …
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Physiological studies with the experimental herbicide isouron
… experiments were conducted to assess the interactions of isouron and four herbicide antidotes on two varieties of corn (Zea mays L.), Dekalb 'XL72AA' and 'XL67', and wheat (Triticum aestivum L.), 'Tyler' and 'McNair 1003'. Antidotes used were naphthalic anhydride (1,8 naphthalic …
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