Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Syncytium"”.
-
Identification of Transmembrane and Extracellular Host Proteases that Promote Human CoV Entry and Syncytium Formation
Coronaviruses (CoVs) comprise a family of enveloped viruses that cause respiratory disease in humans, including CoV disease 2019 (COVID-19), caused by severe-acute respiratory syndrome CoV-2 (SARS-CoV-2). For CoV infection to occur, the CoV spike (S) protein must mediate fusion between the viral …
-
Molecular characterization of CLE peptide mimicry during cyst nematode pathogenesis
… cell to initiate a feeding site known as the syncytium. It has been proposed that the development and maintenance of the syncytium is dependent on secretory effector proteins originating in the esophageal gland cells and delivered into the host root through the nematode stylet. Several …
-
Temporal control of vulval precursor cell fate patterning in Caenorhabditis elegans
… VPCs from fusing with the major hypodermal syncytium in lin-4 null mutants. Finally, through characterization of heterochronic mutants that exhibit precocious or delayed vulval induction, I provide clues to possible mechanisms underlying the temporal control of vulval induction.
-
A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation
… protein are unable to join the skeletogenic syncytium and they fail to repress the transfating of SMCs into the skeletogenic lineage. Thus, FoxN2/3 must be present for the PMC GRN to control normal ingression, expression of skeletal matrix genes, prevention of transfating, and control fusion …
-
Rbfox1 Regulates mRNA Translation to Promote Germ Cell Differentiation
… germ cells that will give rise to oocytes form a syncytium called a germline cyst. The mechanisms that regulate germline cyst development remain poorly understood. In Drosophila, germline stem cells (GSCs) undergo an asymmetric division, giving rise to a stem cell and a cystoblast that then …
-
Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… Furthermore, the mean number of nuclei per syncytium was markedly higher in PARP-overexpressing cells compared to control cells. However, PARP-1 overexpression did not regulate trophoblast hormonal differentiation. In conclusion, PARP-1 does appear to be a key enzyme in the process of …
-
Developmental dynamics of posterior segment addition in the spider Parasteatoda tepidariorum
… formation of segments in Diptera within a syncytium to the sequential addition of segments after cellularisation in most other arthropods. Although the evolution of these mechanisms remains unclear, a set of pair-rule genes (PRGs), regulated by Wnt signalling and the transcription factor …
-
Developing a genetic toolkit for plant-parasitic nematodes
… host genes required for the formation of this syncytium has a negative impact on parasitism: resulting in reduced nematode size and/or a reduction in the infection frequency. Given the intuitive pathways to impact from this fundamental understanding, there is considerable interest in the field …
-
Cell Topology Change by the Physical Engagement of Neighboring Cytoskeletal Networks
Cell topology changes are often associated with neighboring zones of distinct actin cytoskeletal networks and regulators, such as lamellipodium and lamella in migratory cells, branched and unbranched actin networks at cell-cell contacts, and concentric rings of Rho family GTPases during wound …
-
Contribution of the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein to Host Cell Entry and Membrane Fusion
… was completely fusion defective as assessed by syncytium formation assays that measured cell-cell fusion. Likewise, the cell-cell fusion activity for ΔH425 was affected in that the pH threshold required to trigger the fusion event was decreased. These findings support previous reports suggesting …
-
The role of yolk syncytial layer and blastoderm movements during gastrulation in zebrafish
During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and internal organization of the embryo. In teleostean fishes, these morphogenetic movements involve not only the embryonic progenitor cells (deep cells) but also two extra-embryonic tissues: an outer sheet …
-
Developmental biology of heterodera glycines (soybean cyst nematode) and other plant - parasitic nematodes
… H. glycines adult female epidermis comprises a syncytium of approximately 1800 epidermal nuclei, comparison vermiform species C. elegans approximately 140. Saccate shaped development has evolved multiple times among nematodes. To study the evolution of the saccate shape nematode, I study two …
-
The formulation and refinement of a polymerase chain reaction (PCR) assay for early diagnosis of paediatric HIV infection and genetic analysis of variants involved in vertical transmission of HIV-1
… mother and her baby were consistent with the non-syncytium inducing (NSI) phenotype of HIV-1, thus indicating that, contrary to popular belief, NSI variants can be responsible for initiating infection. Data obtained from these genetic investigations of variants involved in vertical transmission of …