Global ETD Search
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Showing 1 to 17 of 17 for “"Syncytiotrophoblast"”.
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Syncytiotrophoblast formation is influenced by genes involved in lipid biology
… and waste exchange occurs in the labyrinth, the syncytiotrophoblast (SynT) cells are the key cell type of this region. Multinucleated SynT cells are formed through the process of trophoblast fusion involving a lipid- signalling event and dynamic membrane rearrangement. Defects altering the …
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Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… fetal health throughout pregnancy. The placental syncytiotrophoblast layer is a key secretory portion of the placenta and is produced through fusion of underlying progenitor cytotrophoblast cells with the multinucleated syncytiotrophoblast layer. The MacPhee laboratory has previously established …
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Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
… luminal cytotrophoblast, and postimplantation syncytiotrophoblast. Marmoset trophectoderm differentiated into syncytiotrophoblast upon implantation but did not form invasive extravillous trophoblast. Staining of in utero embryos demonstrated extensive cytotrophoblast proliferation but …
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Cell lineage choice during differentiation of trophoblast stem cells (tsc) is dependent on oxygen levels, and mediated by stress enzyme pathways and mitochondrial function
… those makers for secondary giant cell and syncytiotrophoblast. Mitochondrial charge is at low levels in TSC maintained by FGF4 at all oxygen levels. Upon FGF4 removal, mitochondrial charge undergoes rapid induction at 20% and 2% O2, but remains low level at 0.5% O2. Using SAPK inhibitors, …
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Ανοσοϊστοχημική μελέτη του πλακούντα με ιδιαίτερη έμφαση στα κύτταρα Hofbauer
… is also reported for the first time. 4. The syncytiotrophoblast showed positive staining for Cytokeratin at all of the three trimester of pregnancy, for EMA only in the third trimester and for a1-AcT and a1-AT in the first trimester. It was consistently unreactive with any of the other …
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The expression and regulation of pregnancy-specific glycoproteins in the mouse
… members and are predominantly expressed in the syncytiotrophoblast of human placenta and in giant cells and spongiotrophoblast of rodent placenta. PSGs are encoded by seventeen genes in the mouse and ten genes in the human. Little is known about the function of this gene family, although they …
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Ryanodine receptor expression in trophoblasts
… of human placental sections indicated that both syncytiotrophoblast and cytotrophoblast cell layers were positively stained by antibodies recognising RyRs; likewise, expression of RyR isoforms was also revealed in BeWo and JEG-3 cells by immunofluorescence microscopy. In addition, changes in …
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The expression of Heat Shock Protein 70 in the placental tissue with preeclampsia
… and the expression of Hsp70 was observed in syncytiotrophoblast, cytotrophoblast, intravillous endothelial cells, extravillous trophoblast in basal layer and decidual cell. And according to the intensity of immunostaining, we compared these three groups. Western blot analysis was performed …
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Role of obesity and gestational diabetes mellitus status on the expression of kisspeptin, inflammatory markers and other endocrine signals, and their correlation with foetal outcomes and placental structure
… kisspeptin gene expression and volume of villous syncytiotrophoblasts and theoretical diffusion capacity in non-obese women irrespective of their GDM status. There was a significant inverse correlation between plasma kisspeptin protein and BMI and maternal systolic blood pressure in GDM women …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… BeWo cells more closely reflected differentiated syncytiotrophoblast. Treatment of primary term trophoblasts in vitro with cytokines (TNF- or IL-1) decreased expression and activity of apical transporters ABCB1/MDR1 and ABCG2/BCRP. Growth factors, on the other hand, increased BCRP expression and …
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Regulation of glucose transporters in sheep placenta
… mRNA was most strongly localised to maternal syncytiotrophoblast and villous tissue, whereas oGLUT3 was predominantly localised to fetal trophoblast cells. Placental oGLUT expression was regulated differently by acute (3 - 8 h) versus long-term (>6 d) alterations in late gestation maternal …
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Placental (Mal)Adaptation in Maternal Obesity: Immune-Mediated Regulation of Placental Nutrient Partitioning and Fetal Growth
… Using primary cultures of term placental syncytiotrophoblasts, the individual and combined acute effects of high glucose, palmitic acid (a representative saturated fat), and pro-inflammatory cytokines (IL1, IL6, TNFα) on nutrient uptake were investigated. These experiments revealed that …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… both 11β-HSD-1 and -2 mRNAs in baboon placental syncytiotrophoblast-enriched fractions following reduction of maternal serum estrogen <em>in vivo</em> by a highly-specific P450-aromatase enzyme inhibitor, CGS 20267.</p>
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Expression and activity of enzymes in the human placenta: pharmacological & toxicological consequences in AZT therapy
… placentas. The localisation of XME (the syncytiotrophoblast layer bordering the placental villi) did not change with gestation but enzyme activity and affinity did. Greater activify but lower affinity of UGT and CYPIA were observed in first trimester placentas than at term. In contrast, …
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Role of Histone Lysine Demethylase, KDM1B, in Trophoblast Stem Cell Self-Renewal and Differentiation
… of precocious differentiation into the syncytiotrophoblast lineage. By performing a large cohort of integrated genome-wide analyses, notably RNA-seq and chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) for the relevant histone modifications H3K4me1, …
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Hyperosmotic Stress Enzyme Signaling Modulates Oct4, Nanog, And Rex1 Expression And Induces Prioritized Differentiation Of Murine Embryonic Stem Cells
… laterdifferentiating</p> <p>lineages (chorionic/syncytiotrophoblast).</p> <p>The studies described in this dissertation studied the stress response of the other</p> <p>extant lineage of the early blastocyst, cells derived from the inner cell mass, murine</p> <p>embryonic stem cells (mESC). …
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Acetyl-CoA metabolism and human trophoblast differentiation
… levels which declines with differentiation into syncytiotrophoblast or extravillous trophoblasts. It was further demonstrated that during trophoblast differentiation, changes in histone acetylation precede changes in markers associated with differentiation, suggesting that metabolic and …