Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Synaptopathy"”.
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Auditory brainstem response latency in noise as a marker of cochlear synaptopathy
… studies, such noise exposure leads to cochlear synaptopathy (death of auditory nerve fibers or ANFs); however, there is no clinical test of synaptopathy in humans. In animals, synaptopathy reduces the amplitude of auditory brainstem response (ABR) wave-I. Unfortunately, ABR wave-I is difficult …
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Repurposing Oseltamivir, a Commonly Prescribed Influenza Antiviral, for the Prevention of Noise- and Cisplatin-Induced Hearing Loss
… after cisplatin treatment and mitigated cochlear synaptopathy after noise exposure. We showed that a potential binding protein, ERK1/2, associated with inflammation, was activated with cisplatin treatment and reduced with oseltamivir cotreatment in cochlear explants. Importantly, we also …
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Hear Today, Gone Tomorrow: Exploring Quinoxaline Derivatives as a Treatment for Noise-Induced Hearing Loss
… Qx34, and Qx62 – in an in vivo mouse model for synaptopathy. Their therapeutic effects were quantified using auditory brainstem responses (ABR), distortion product otoacoustic emissions (DPOAE), and morphological analysis. The derivatives’ bioavailability was assessed using an in silico ADME …
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The Master Synaptic Regulator: Activity Regulated Cytoskeleton Associated Protein, Arc, in Normal Aging and Diseases with Cognitive Impairment
… age and in AD. The altered Arc contributes to synaptopathy in AD through its interactions at the postsynaptic density and dendritic spine. However, the mechanisms responsible for Arc alteration during normal aging and in AD are currently not clear.</p> <p>In these studies, we systemically …
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Mechanism of CASK-linked ophthalmological disorders
… cells (RGC), astrogliosis, axonopathy, and synaptopathy. The onset of ONH is late in development, observed only around the early postnatal stage in mice reaching the plateau phase by three weeks of birth. The developmental nature of the disorder is confirmed by deleting CASK after maturity …